UGT85

Reinventing metabolic

Substrate reaction site Product reaction site MCS substructure diff highlighting · RDKit atom mapping

Substrate

2,4-dihydroxy-1,4-benzoxazin-3-one (DIBOA)

PubChem ↗ C1=CC=C2C(=C1)N(C(=O)C(O2)O)O

UGT85

ΔMass: +162.0528 Da mismatch

Product

DIBOA-Glc

PubChem ↗ C1=CC=C2C(=C1)N(C(=O)C(O2)OC3C(C(C(C(O3)CO)O)O)O)O

Evidence trail

Excerpts are machine-extracted plain text for biochemical provenance. Follow DOI / PubMed links for the primary literature; publisher figures and PDF images are not displayed here.

Source text excerpt ation; ation; LgBX8 from Lamium galeobdolon glucosylates DIBOA to DIBOA-Glc, demonstrated in vitro with purified enzyme and in N. benthamiana.

Reaction & quality gates

Mechanism: Glycosylation
Evidence type: In vitro
Confidence: High
Data tier: Quarantine
non-CYP auxiliary enzyme (pathway partner, not cytochrome P450)
Substrate class: Other
Product class: Glycosides

Literature & public identifiers

PubMed: PMID:37812727 ↗
DOI: 10.1073/pnas.2307981120 ↗
UniProt: —
GenBank: —
NCBI TaxID: —

Reinventing metabolic pathways: Independent evolution of benzoxazinoids in flowering plants.