Campaign C ยท Audit Console
Quarantine audit archive
Self-purifying pipeline log ยท intercepts NLP semantic traps, literature source errors, and negative catalytic evidence. We never blindly ingest junk data.
208TOTAL QUARANTINED
1LITERATURE_ERROR
0NEGATIVE_EVIDENCE
Interception reason matrix
Literature Error
1
Compound names from source text fail PubChem/RDKit resolution โ upstream typo, not pipeline failure.
Negative Evidence 0NLP detected negative catalysis phrasing (not involved, no detection) โ blocks false positives.
Non-P450 Partner 205Pathway partners (sulfotransferases, UGTs, etc.) kept for context but excluded from the CYP set.
Species NLP Trap 0Functional phrases mis-tagged as Latin binomials, or garbage pseudo-species strings.
Manual Review 2Ambiguous enzyme names, mass-gate failures, or other curator-review items.
Recent quarantine entries
Open in reaction grid โ| Status | Enzyme / species | Reaction | Reason | Evidence excerpt | PMID |
|---|---|---|---|---|---|
| Review |
ZmTPS10 Zea mays |
farnesyl diphosphate โ (E)-ฮฒ-farnesene | non-CYP auxiliary enzyme (pathway partner, not cytochrome P450) | Other; Other; ZmTPS10 is a terpene synthase, not a P450; included per rules for TPS? The rules state non-CYP enzymes (UGT, OSC, PAL) must not be written. Howevโฆ | 42096114 โ |
| Review |
FLS Ziziphus jujuba |
dihydroflavonol โ flavonol | non-CYP auxiliary enzyme (pathway partner, not cytochrome P450) | ation; ation; Section 3: ZjFLS heterologous expression in Arabidopsis increased TFC 3.67-fold; transient overexpression in jujube increased quercetin-3-O-rutinโฆ | 42075362 โ |
| Review |
FLS Ziziphus jujuba |
dihydroflavonol โ quercetin | non-CYP auxiliary enzyme (pathway partner, not cytochrome P450) | ation; ation; Section 3: ZjFLS1 and ZjFLS2 transient overexpression increased quercetin-3-O-rutinoside; silencing inhibited quercetin-3-O-glucoside and quercetโฆ | 42075362 โ |
| Review |
FLS Ziziphus jujuba |
dihydroflavonol โ quercetin | non-CYP auxiliary enzyme (pathway partner, not cytochrome P450) | ation; ation; Section 3: ZjFLS1 and ZjFLS2 transient overexpression increased quercetin-3-O-rutinoside; silencing inhibited quercetin-3-O-glucoside and quercetโฆ | 42075362 โ |
| Review |
UGT79B1 Ziziphus jujuba |
anthocyanidin โ cyanidin-3-O-rutinoside | non-CYP auxiliary enzyme (pathway partner, not cytochrome P450) | ation; ation; Section 3: ZjMYB5, ZjTT8, and ZjWDR3 activated promoters of ZjANS and ZjUGT79B1, increasing cyanidin-3-O-rutinoside and peonidin-3,5-O-diglucosidโฆ | 42075362 โ |
| Review |
UGT79B1 Ziziphus jujuba |
anthocyanidin โ peonidin-3,5-O-diglucoside | non-CYP auxiliary enzyme (pathway partner, not cytochrome P450) | ation; ation; Section 3: ZjMYB5, ZjTT8, and ZjWDR3 activated promoters of ZjANS and ZjUGT79B1, increasing cyanidin-3-O-rutinoside and peonidin-3,5-O-diglucosidโฆ | 42075362 โ |
| Review |
PAL NEEDS_SALVAGE |
L-phenylalanine โ cinnamic acid | non-CYP auxiliary enzyme (pathway partner, not cytochrome P450) | ation; ation; Heterologous expression in S. cerevisiae; p-HCA production confirmed via HPLC and HRMS. | 42038009 โ |
| Review |
BcUGT009 Belamcanda chinensis |
iristectorigenin B โ iristectorin B | non-CYP auxiliary enzyme (pathway partner, not cytochrome P450) | ation; ation; 7-O-glucosylation; kinetic data provided. | 41830405 โ |
| Review |
BcUGT009 Belamcanda chinensis |
iristectorigenin B โ iristectorin B | non-CYP auxiliary enzyme (pathway partner, not cytochrome P450) | ation; ation; Confirmed by Nicotiana benthamiana transient expression. | 41830405 โ |
| Review |
BcUGT032 Belamcanda chinensis |
irigenin โ iridin | non-CYP auxiliary enzyme (pathway partner, not cytochrome P450) | ation; ation; 7-O-glucosylation; kinetic data provided. | 41830405 โ |
| Review |
BcUGT032 Belamcanda chinensis |
irigenin โ iridin | non-CYP auxiliary enzyme (pathway partner, not cytochrome P450) | ation; ation; Confirmed by Nicotiana benthamiana transient expression; product detected by LC/MS. | 41830405 โ |
| Review |
BcUGT119 Belamcanda chinensis |
iristectorigenin A โ iristectorin A | non-CYP auxiliary enzyme (pathway partner, not cytochrome P450) | ation; ation; 7-O-glucosylation; kinetic data provided. | 41830405 โ |
| Review |
BcUGT119 Belamcanda chinensis |
iristectorigenin A โ iristectorin A | non-CYP auxiliary enzyme (pathway partner, not cytochrome P450) | ation; ation; Confirmed by Nicotiana benthamiana transient expression. | 41830405 โ |
| Review |
BcUGT124 Belamcanda chinensis |
tectorigenin โ tectoridin | non-CYP auxiliary enzyme (pathway partner, not cytochrome P450) | ation; ation; 7-O-glucosylation; kinetic data provided. | 41830405 โ |
| Review |
BcUGT124 Belamcanda chinensis |
tectorigenin โ tectoridin | non-CYP auxiliary enzyme (pathway partner, not cytochrome P450) | ation; ation; Confirmed by Nicotiana benthamiana transient expression. | 41830405 โ |
| Review |
ODMT Glycyrrhiza glabra |
formononetin โ daidzein | non-CYP auxiliary enzyme (pathway partner, not cytochrome P450) | ation; ation; PMID 41782076, in vitro assay with recombinant GgODMT, O-demethylation of 4'-OCH3 to 4'-OH. | 41782076 โ |
| Review |
ODMT Glycyrrhiza glabra |
vestitone โ 2'-hydroxydaidzein | non-CYP auxiliary enzyme (pathway partner, not cytochrome P450) | ation; ation; PMID 41782076, in vitro assay with recombinant GgODMT, O-demethylation of 4'-OCH3 to 4'-OH. | 41782076 โ |
| Review |
ODMT Glycyrrhiza glabra |
medicarpin โ demethylmedicarpin | non-CYP auxiliary enzyme (pathway partner, not cytochrome P450) | ation; ation; PMID 41782076, in vitro assay with recombinant GgODMT, O-demethylation of 4'-OCH3 to 4'-OH. | 41782076 โ |
| Review |
ODMT Glycyrrhiza glabra |
vestitol โ demethylvestitol | non-CYP auxiliary enzyme (pathway partner, not cytochrome P450) | ation; ation; PMID 41782076, in vitro assay with recombinant GgODMT, O-demethylation of 4'-OCH3 to 4'-OH. | 41782076 โ |
| Review |
ODMT Glycyrrhiza glabra |
4'-O-methylpreglabridin โ preglabridin | non-CYP auxiliary enzyme (pathway partner, not cytochrome P450) | ation; ation; PMID 41782076, in vitro assay with recombinant GgODMT, O-demethylation of 4'-OCH3 to 4'-OH. | 41782076 โ |
| Review |
ODMT Glycyrrhiza glabra |
4'-O-methylglabridin โ glabridin | non-CYP auxiliary enzyme (pathway partner, not cytochrome P450) | ation; ation; PMID 41782076, in vitro assay with recombinant GgODMT, O-demethylation of 4'-OCH3 to 4'-OH. | 41782076 โ |
| Review |
TPS1 Mosla chinensis |
geranyl diphosphate โ ฮณ-terpinene | non-CYP auxiliary enzyme (pathway partner, not cytochrome P450) | ization; ization; In vitro assay with GPP as substrate; product confirmed by GC-MS. | 41631144 โ |
| Review |
TPS2 Mosla chinensis |
geranyl diphosphate โ cineole | non-CYP auxiliary enzyme (pathway partner, not cytochrome P450) | ization; ization; In vitro assay with GPP as substrate; product confirmed by GC-MS. | 41631144 โ |
| Review |
TPS3 Mosla chinensis |
geranyl diphosphate โ linalool | non-CYP auxiliary enzyme (pathway partner, not cytochrome P450) | ization; ization; In vitro assay with GPP as substrate; product confirmed by GC-MS. | 41631144 โ |
| Review |
TPS4 Mosla chinensis |
geranyl diphosphate โ ฮฑ-pinene | non-CYP auxiliary enzyme (pathway partner, not cytochrome P450) | ization; ization; In vitro assay with GPP as substrate; product confirmed by GC-MS. | 41631144 โ |
| Review |
TPS4 Mosla chinensis |
geranyl diphosphate โ ฮฒ-pinene | non-CYP auxiliary enzyme (pathway partner, not cytochrome P450) | ization; ization; In vitro assay with GPP as substrate; product confirmed by GC-MS. | 41631144 โ |
| Review |
TPS5 Mosla chinensis |
geranyl diphosphate โ ฮฑ-pinene | non-CYP auxiliary enzyme (pathway partner, not cytochrome P450) | ization; ization; In vitro assay with GPP as substrate; product confirmed by GC-MS. | 41631144 โ |
| Review |
TPS5 Mosla chinensis |
geranyl diphosphate โ ฮฒ-pinene | non-CYP auxiliary enzyme (pathway partner, not cytochrome P450) | ization; ization; In vitro assay with GPP as substrate; product confirmed by GC-MS. | 41631144 โ |
| Review |
TPS5 Mosla chinensis |
geranyl diphosphate โ camphene | non-CYP auxiliary enzyme (pathway partner, not cytochrome P450) | ization; ization; In vitro assay with GPP as substrate; product confirmed by GC-MS. | 41631144 โ |
| Review |
CkTPS10 Curcuma kwangsiensis |
farnesyl pyrophosphate โ ฮฑ-copaene | non-CYP auxiliary enzyme (pathway partner, not cytochrome P450) | ization; ization; Heterologous expression in Saccharomyces cerevisiae with FPP substrate; GC-MS identified ฮฑ-copaene as a major product. | 41415678 โ |
| Review |
CkTPS10 Curcuma kwangsiensis |
farnesyl pyrophosphate โ farnesol | non-CYP auxiliary enzyme (pathway partner, not cytochrome P450) | ysis; ysis; Heterologous expression in Saccharomyces cerevisiae with FPP substrate; GC-MS identified farnesol as a major product. | 41415678 โ |
| Review |
HYC3O Rauvolfia tetraphylla |
rauwolscine โ 3-dehydro-rauwolscine | non-CYP auxiliary enzyme (pathway partner, not cytochrome P450) | ation; ation; Rauvolfia tetraphylla HYC3O; purified recombinant protein; LC-MS/MS and NMR confirmed. | 41290611 โ |
| Review |
HYC3O Rauvolfia tetraphylla |
yohimbine โ 3-dehydro-yohimbine | non-CYP auxiliary enzyme (pathway partner, not cytochrome P450) | ation; ation; Rauvolfia tetraphylla HYC3O; purified recombinant protein; LC-MS/MS and UV confirmed. | 41290611 โ |
| Review |
HYC3O Rauvolfia tetraphylla |
alloyohimbine โ 3-dehydro-alloyohimbine | non-CYP auxiliary enzyme (pathway partner, not cytochrome P450) | ation; ation; Rauvolfia tetraphylla HYC3O; purified recombinant protein; LC-MS/MS and UV confirmed. | 41290611 โ |
| Review |
HYC3O Rauvolfia tetraphylla |
ajmalicine โ 3-dehydro-ajmalicine | non-CYP auxiliary enzyme (pathway partner, not cytochrome P450) | ation; ation; Rauvolfia tetraphylla HYC3O; purified recombinant protein; LC-MS/MS and UV confirmed. | 41290611 โ |
| Review |
HYC3O Rauvolfia tetraphylla |
tetrahydroalstonine โ 3-dehydro-tetrahydroalstonine | non-CYP auxiliary enzyme (pathway partner, not cytochrome P450) | ation; ation; Rauvolfia tetraphylla HYC3O; purified recombinant protein; LC-MS/MS and UV confirmed. | 41290611 โ |
| Review |
HYC3O Rauvolfia tetraphylla |
corynantheidine โ 3-dehydro-corynantheidine | non-CYP auxiliary enzyme (pathway partner, not cytochrome P450) | ation; ation; Rauvolfia tetraphylla HYC3O; purified recombinant protein; LC-MS/MS and UV confirmed. | 41290611 โ |
| Review |
HYC3O Rauvolfia tetraphylla |
mitragynine โ 3-dehydro-mitragynine | non-CYP auxiliary enzyme (pathway partner, not cytochrome P450) | ation; ation; Rauvolfia tetraphylla HYC3O; purified recombinant protein; LC-MS/MS and UV confirmed. | 41290611 โ |
| Review |
HYC3R Rauvolfia tetraphylla |
3-dehydro-rauwolscine โ 3-epi-rauwolscine | non-CYP auxiliary enzyme (pathway partner, not cytochrome P450) | ion; ion; Rauvolfia serpentina RsCAD7; purified recombinant protein; LC-MS/MS and NMR confirmed. | 41290611 โ |
| Review |
HYC3R Rauvolfia tetraphylla |
3-dehydro-yohimbine โ 3-epi-yohimbine | non-CYP auxiliary enzyme (pathway partner, not cytochrome P450) | ion; ion; Rauvolfia serpentina RsCAD7; purified recombinant protein; LC-MS/MS and UV confirmed. | 41290611 โ |
| Review |
HYC3R Rauvolfia tetraphylla |
3-dehydro-ajmalicine โ 3-epi-ajmalicine | non-CYP auxiliary enzyme (pathway partner, not cytochrome P450) | ion; ion; Rauvolfia serpentina RsCAD7; purified recombinant protein; LC-MS/MS and UV confirmed. | 41290611 โ |
| Review |
HYC3R Rauvolfia tetraphylla |
3-dehydro-tetrahydroalstonine โ 3-epi-tetrahydroalstonine | non-CYP auxiliary enzyme (pathway partner, not cytochrome P450) | ion; ion; Rauvolfia serpentina RsCAD7; purified recombinant protein; LC-MS/MS and UV confirmed. | 41290611 โ |
| Review |
PKS1 Unknown |
3-methylorsellinic acid โ 4-O-demethylbarbatic acid | non-CYP auxiliary enzyme (pathway partner, not cytochrome P450) | Other; Other; Heterologous expression of pks1s in Aspergillus oryzae NSAR1 produced 4-O-demethylbarbatic acid (PMID: 41225761). | 41225761 โ |
| Review |
PKS23 Unknown |
3-methylorsellinic acid โ 4-O-demethylbarbatic acid | non-CYP auxiliary enzyme (pathway partner, not cytochrome P450) | Other; Other; Heterologous expression in Aspergillus oryzae NSAR1 confirmed production of 4-O-demethylbarbatic acid from pks23 (PMID: 41225761). | 41225761 โ |
| Review |
CYP450 Iterative cascade |
ฮฒ-amyrin โ quillaic acid | vague_enzyme | ation; ๆจก็ณ้ ถๅๅทฒๅ้ค: CYP450; ation; ๅๆ้ ถๅญๆฎต: CYP450 (quininic acid oxidase); Iterative cascade of CYP450 oxidations converting ฮฒ-amyrin to quillaic acid in engineeredโฆ | 41161185 โ |
| Review |
CwTPS8 Curcuma wenyujin |
farnesyl pyrophosphate โ alpha-humulene | non-CYP auxiliary enzyme (pathway partner, not cytochrome P450) | ization; ization; In vitro enzyme assay with purified recombinant CwTPS8 and FPP; GC-MS confirmed alpha-humulene as a major product. | 41114138 โ |
| Review |
CwTPS8 Curcuma wenyujin |
farnesyl pyrophosphate โ beta-caryophyllene | non-CYP auxiliary enzyme (pathway partner, not cytochrome P450) | ization; ization; In vitro enzyme assay with purified recombinant CwTPS8 and FPP; GC-MS confirmed beta-caryophyllene as a major product. | 41114138 โ |
| Review |
MnCHS Morus notabilis |
p-coumaroyl-CoA โ naringenin | non-CYP auxiliary enzyme (pathway partner, not cytochrome P450) | ization; ization; MnCHS converts p-coumaroyl-CoA to naringenin via chalcone intermediate; in vitro enzyme assay with purified recombinant protein. | 41112970 โ |
| Review |
MnCHS Morus notabilis |
2,4-dihydroxycinnamoyl-CoA โ steppogenin | non-CYP auxiliary enzyme (pathway partner, not cytochrome P450) | ization; ization; MnCHS converts 2,4-dihydroxycinnamoyl-CoA to steppogenin; in vitro enzyme assay with purified recombinant protein. | 41112970 โ |
| Review |
MnFLS Morus notabilis |
dihydrokaempferol โ kaempferol | non-CYP auxiliary enzyme (pathway partner, not cytochrome P450) | ation; ation; MnFLS converts dihydrokaempferol to kaempferol; in vitro enzyme assay with purified recombinant protein. | 41112970 โ |