Campaign C Β· Audit Console

Quarantine audit archive

Self-purifying pipeline log Β· intercepts NLP semantic traps, literature source errors, and negative catalytic evidence. We never blindly ingest junk data.

208TOTAL QUARANTINED
1LITERATURE_ERROR
0NEGATIVE_EVIDENCE

Interception reason matrix

Non-P450 Partner Β· 205 entries

Open in reaction grid β†’
Status Enzyme / species Reaction Reason Evidence excerpt PMID
Review ZmTPS10
Zea mays
farnesyl diphosphate β†’ (E)-Ξ²-farnesene non-CYP auxiliary enzyme (pathway partner, not cytochrome P450) Other; Other; ZmTPS10 is a terpene synthase, not a P450; included per rules for TPS? The rules state non-CYP enzymes (UGT, OSC, PAL) must not be written. Howev… 42096114 β†—
Review FLS
Ziziphus jujuba
dihydroflavonol β†’ flavonol non-CYP auxiliary enzyme (pathway partner, not cytochrome P450) ation; ation; Section 3: ZjFLS heterologous expression in Arabidopsis increased TFC 3.67-fold; transient overexpression in jujube increased quercetin-3-O-rutin… 42075362 β†—
Review FLS
Ziziphus jujuba
dihydroflavonol β†’ quercetin non-CYP auxiliary enzyme (pathway partner, not cytochrome P450) ation; ation; Section 3: ZjFLS1 and ZjFLS2 transient overexpression increased quercetin-3-O-rutinoside; silencing inhibited quercetin-3-O-glucoside and quercet… 42075362 β†—
Review FLS
Ziziphus jujuba
dihydroflavonol β†’ quercetin non-CYP auxiliary enzyme (pathway partner, not cytochrome P450) ation; ation; Section 3: ZjFLS1 and ZjFLS2 transient overexpression increased quercetin-3-O-rutinoside; silencing inhibited quercetin-3-O-glucoside and quercet… 42075362 β†—
Review UGT79B1
Ziziphus jujuba
anthocyanidin β†’ cyanidin-3-O-rutinoside non-CYP auxiliary enzyme (pathway partner, not cytochrome P450) ation; ation; Section 3: ZjMYB5, ZjTT8, and ZjWDR3 activated promoters of ZjANS and ZjUGT79B1, increasing cyanidin-3-O-rutinoside and peonidin-3,5-O-diglucosid… 42075362 β†—
Review UGT79B1
Ziziphus jujuba
anthocyanidin β†’ peonidin-3,5-O-diglucoside non-CYP auxiliary enzyme (pathway partner, not cytochrome P450) ation; ation; Section 3: ZjMYB5, ZjTT8, and ZjWDR3 activated promoters of ZjANS and ZjUGT79B1, increasing cyanidin-3-O-rutinoside and peonidin-3,5-O-diglucosid… 42075362 β†—
Review PAL
NEEDS_SALVAGE
L-phenylalanine β†’ cinnamic acid non-CYP auxiliary enzyme (pathway partner, not cytochrome P450) ation; ation; Heterologous expression in S. cerevisiae; p-HCA production confirmed via HPLC and HRMS. 42038009 β†—
Review BcUGT009
Belamcanda chinensis
iristectorigenin B β†’ iristectorin B non-CYP auxiliary enzyme (pathway partner, not cytochrome P450) ation; ation; 7-O-glucosylation; kinetic data provided. 41830405 β†—
Review BcUGT009
Belamcanda chinensis
iristectorigenin B β†’ iristectorin B non-CYP auxiliary enzyme (pathway partner, not cytochrome P450) ation; ation; Confirmed by Nicotiana benthamiana transient expression. 41830405 β†—
Review BcUGT032
Belamcanda chinensis
irigenin β†’ iridin non-CYP auxiliary enzyme (pathway partner, not cytochrome P450) ation; ation; 7-O-glucosylation; kinetic data provided. 41830405 β†—
Review BcUGT032
Belamcanda chinensis
irigenin β†’ iridin non-CYP auxiliary enzyme (pathway partner, not cytochrome P450) ation; ation; Confirmed by Nicotiana benthamiana transient expression; product detected by LC/MS. 41830405 β†—
Review BcUGT119
Belamcanda chinensis
iristectorigenin A β†’ iristectorin A non-CYP auxiliary enzyme (pathway partner, not cytochrome P450) ation; ation; 7-O-glucosylation; kinetic data provided. 41830405 β†—
Review BcUGT119
Belamcanda chinensis
iristectorigenin A β†’ iristectorin A non-CYP auxiliary enzyme (pathway partner, not cytochrome P450) ation; ation; Confirmed by Nicotiana benthamiana transient expression. 41830405 β†—
Review BcUGT124
Belamcanda chinensis
tectorigenin β†’ tectoridin non-CYP auxiliary enzyme (pathway partner, not cytochrome P450) ation; ation; 7-O-glucosylation; kinetic data provided. 41830405 β†—
Review BcUGT124
Belamcanda chinensis
tectorigenin β†’ tectoridin non-CYP auxiliary enzyme (pathway partner, not cytochrome P450) ation; ation; Confirmed by Nicotiana benthamiana transient expression. 41830405 β†—
Review ODMT
Glycyrrhiza glabra
formononetin β†’ daidzein non-CYP auxiliary enzyme (pathway partner, not cytochrome P450) ation; ation; PMID 41782076, in vitro assay with recombinant GgODMT, O-demethylation of 4'-OCH3 to 4'-OH. 41782076 β†—
Review ODMT
Glycyrrhiza glabra
vestitone β†’ 2'-hydroxydaidzein non-CYP auxiliary enzyme (pathway partner, not cytochrome P450) ation; ation; PMID 41782076, in vitro assay with recombinant GgODMT, O-demethylation of 4'-OCH3 to 4'-OH. 41782076 β†—
Review ODMT
Glycyrrhiza glabra
medicarpin β†’ demethylmedicarpin non-CYP auxiliary enzyme (pathway partner, not cytochrome P450) ation; ation; PMID 41782076, in vitro assay with recombinant GgODMT, O-demethylation of 4'-OCH3 to 4'-OH. 41782076 β†—
Review ODMT
Glycyrrhiza glabra
vestitol β†’ demethylvestitol non-CYP auxiliary enzyme (pathway partner, not cytochrome P450) ation; ation; PMID 41782076, in vitro assay with recombinant GgODMT, O-demethylation of 4'-OCH3 to 4'-OH. 41782076 β†—
Review ODMT
Glycyrrhiza glabra
4'-O-methylpreglabridin β†’ preglabridin non-CYP auxiliary enzyme (pathway partner, not cytochrome P450) ation; ation; PMID 41782076, in vitro assay with recombinant GgODMT, O-demethylation of 4'-OCH3 to 4'-OH. 41782076 β†—
Review ODMT
Glycyrrhiza glabra
4'-O-methylglabridin β†’ glabridin non-CYP auxiliary enzyme (pathway partner, not cytochrome P450) ation; ation; PMID 41782076, in vitro assay with recombinant GgODMT, O-demethylation of 4'-OCH3 to 4'-OH. 41782076 β†—
Review TPS1
Mosla chinensis
geranyl diphosphate β†’ Ξ³-terpinene non-CYP auxiliary enzyme (pathway partner, not cytochrome P450) ization; ization; In vitro assay with GPP as substrate; product confirmed by GC-MS. 41631144 β†—
Review TPS2
Mosla chinensis
geranyl diphosphate β†’ cineole non-CYP auxiliary enzyme (pathway partner, not cytochrome P450) ization; ization; In vitro assay with GPP as substrate; product confirmed by GC-MS. 41631144 β†—
Review TPS3
Mosla chinensis
geranyl diphosphate β†’ linalool non-CYP auxiliary enzyme (pathway partner, not cytochrome P450) ization; ization; In vitro assay with GPP as substrate; product confirmed by GC-MS. 41631144 β†—
Review TPS4
Mosla chinensis
geranyl diphosphate β†’ Ξ±-pinene non-CYP auxiliary enzyme (pathway partner, not cytochrome P450) ization; ization; In vitro assay with GPP as substrate; product confirmed by GC-MS. 41631144 β†—
Review TPS4
Mosla chinensis
geranyl diphosphate β†’ Ξ²-pinene non-CYP auxiliary enzyme (pathway partner, not cytochrome P450) ization; ization; In vitro assay with GPP as substrate; product confirmed by GC-MS. 41631144 β†—
Review TPS5
Mosla chinensis
geranyl diphosphate β†’ Ξ±-pinene non-CYP auxiliary enzyme (pathway partner, not cytochrome P450) ization; ization; In vitro assay with GPP as substrate; product confirmed by GC-MS. 41631144 β†—
Review TPS5
Mosla chinensis
geranyl diphosphate β†’ Ξ²-pinene non-CYP auxiliary enzyme (pathway partner, not cytochrome P450) ization; ization; In vitro assay with GPP as substrate; product confirmed by GC-MS. 41631144 β†—
Review TPS5
Mosla chinensis
geranyl diphosphate β†’ camphene non-CYP auxiliary enzyme (pathway partner, not cytochrome P450) ization; ization; In vitro assay with GPP as substrate; product confirmed by GC-MS. 41631144 β†—
Review CkTPS10
Curcuma kwangsiensis
farnesyl pyrophosphate β†’ Ξ±-copaene non-CYP auxiliary enzyme (pathway partner, not cytochrome P450) ization; ization; Heterologous expression in Saccharomyces cerevisiae with FPP substrate; GC-MS identified Ξ±-copaene as a major product. 41415678 β†—
Review CkTPS10
Curcuma kwangsiensis
farnesyl pyrophosphate β†’ farnesol non-CYP auxiliary enzyme (pathway partner, not cytochrome P450) ysis; ysis; Heterologous expression in Saccharomyces cerevisiae with FPP substrate; GC-MS identified farnesol as a major product. 41415678 β†—
Review HYC3O
Rauvolfia tetraphylla
rauwolscine β†’ 3-dehydro-rauwolscine non-CYP auxiliary enzyme (pathway partner, not cytochrome P450) ation; ation; Rauvolfia tetraphylla HYC3O; purified recombinant protein; LC-MS/MS and NMR confirmed. 41290611 β†—
Review HYC3O
Rauvolfia tetraphylla
yohimbine β†’ 3-dehydro-yohimbine non-CYP auxiliary enzyme (pathway partner, not cytochrome P450) ation; ation; Rauvolfia tetraphylla HYC3O; purified recombinant protein; LC-MS/MS and UV confirmed. 41290611 β†—
Review HYC3O
Rauvolfia tetraphylla
alloyohimbine β†’ 3-dehydro-alloyohimbine non-CYP auxiliary enzyme (pathway partner, not cytochrome P450) ation; ation; Rauvolfia tetraphylla HYC3O; purified recombinant protein; LC-MS/MS and UV confirmed. 41290611 β†—
Review HYC3O
Rauvolfia tetraphylla
ajmalicine β†’ 3-dehydro-ajmalicine non-CYP auxiliary enzyme (pathway partner, not cytochrome P450) ation; ation; Rauvolfia tetraphylla HYC3O; purified recombinant protein; LC-MS/MS and UV confirmed. 41290611 β†—
Review HYC3O
Rauvolfia tetraphylla
tetrahydroalstonine β†’ 3-dehydro-tetrahydroalstonine non-CYP auxiliary enzyme (pathway partner, not cytochrome P450) ation; ation; Rauvolfia tetraphylla HYC3O; purified recombinant protein; LC-MS/MS and UV confirmed. 41290611 β†—
Review HYC3O
Rauvolfia tetraphylla
corynantheidine β†’ 3-dehydro-corynantheidine non-CYP auxiliary enzyme (pathway partner, not cytochrome P450) ation; ation; Rauvolfia tetraphylla HYC3O; purified recombinant protein; LC-MS/MS and UV confirmed. 41290611 β†—
Review HYC3O
Rauvolfia tetraphylla
mitragynine β†’ 3-dehydro-mitragynine non-CYP auxiliary enzyme (pathway partner, not cytochrome P450) ation; ation; Rauvolfia tetraphylla HYC3O; purified recombinant protein; LC-MS/MS and UV confirmed. 41290611 β†—
Review HYC3R
Rauvolfia tetraphylla
3-dehydro-rauwolscine β†’ 3-epi-rauwolscine non-CYP auxiliary enzyme (pathway partner, not cytochrome P450) ion; ion; Rauvolfia serpentina RsCAD7; purified recombinant protein; LC-MS/MS and NMR confirmed. 41290611 β†—
Review HYC3R
Rauvolfia tetraphylla
3-dehydro-yohimbine β†’ 3-epi-yohimbine non-CYP auxiliary enzyme (pathway partner, not cytochrome P450) ion; ion; Rauvolfia serpentina RsCAD7; purified recombinant protein; LC-MS/MS and UV confirmed. 41290611 β†—
Review HYC3R
Rauvolfia tetraphylla
3-dehydro-ajmalicine β†’ 3-epi-ajmalicine non-CYP auxiliary enzyme (pathway partner, not cytochrome P450) ion; ion; Rauvolfia serpentina RsCAD7; purified recombinant protein; LC-MS/MS and UV confirmed. 41290611 β†—
Review HYC3R
Rauvolfia tetraphylla
3-dehydro-tetrahydroalstonine β†’ 3-epi-tetrahydroalstonine non-CYP auxiliary enzyme (pathway partner, not cytochrome P450) ion; ion; Rauvolfia serpentina RsCAD7; purified recombinant protein; LC-MS/MS and UV confirmed. 41290611 β†—
Review PKS1
Unknown
3-methylorsellinic acid β†’ 4-O-demethylbarbatic acid non-CYP auxiliary enzyme (pathway partner, not cytochrome P450) Other; Other; Heterologous expression of pks1s in Aspergillus oryzae NSAR1 produced 4-O-demethylbarbatic acid (PMID: 41225761). 41225761 β†—
Review PKS23
Unknown
3-methylorsellinic acid β†’ 4-O-demethylbarbatic acid non-CYP auxiliary enzyme (pathway partner, not cytochrome P450) Other; Other; Heterologous expression in Aspergillus oryzae NSAR1 confirmed production of 4-O-demethylbarbatic acid from pks23 (PMID: 41225761). 41225761 β†—
Review CwTPS8
Curcuma wenyujin
farnesyl pyrophosphate β†’ alpha-humulene non-CYP auxiliary enzyme (pathway partner, not cytochrome P450) ization; ization; In vitro enzyme assay with purified recombinant CwTPS8 and FPP; GC-MS confirmed alpha-humulene as a major product. 41114138 β†—
Review CwTPS8
Curcuma wenyujin
farnesyl pyrophosphate β†’ beta-caryophyllene non-CYP auxiliary enzyme (pathway partner, not cytochrome P450) ization; ization; In vitro enzyme assay with purified recombinant CwTPS8 and FPP; GC-MS confirmed beta-caryophyllene as a major product. 41114138 β†—
Review MnCHS
Morus notabilis
p-coumaroyl-CoA β†’ naringenin non-CYP auxiliary enzyme (pathway partner, not cytochrome P450) ization; ization; MnCHS converts p-coumaroyl-CoA to naringenin via chalcone intermediate; in vitro enzyme assay with purified recombinant protein. 41112970 β†—
Review MnCHS
Morus notabilis
2,4-dihydroxycinnamoyl-CoA β†’ steppogenin non-CYP auxiliary enzyme (pathway partner, not cytochrome P450) ization; ization; MnCHS converts 2,4-dihydroxycinnamoyl-CoA to steppogenin; in vitro enzyme assay with purified recombinant protein. 41112970 β†—
Review MnFLS
Morus notabilis
dihydrokaempferol β†’ kaempferol non-CYP auxiliary enzyme (pathway partner, not cytochrome P450) ation; ation; MnFLS converts dihydrokaempferol to kaempferol; in vitro enzyme assay with purified recombinant protein. 41112970 β†—
Review MnFLS
Morus notabilis
naringenin β†’ dihydrokaempferol non-CYP auxiliary enzyme (pathway partner, not cytochrome P450) ation; ation; MnFLS converts naringenin to dihydrokaempferol (F3H activity); in vitro enzyme assay with purified recombinant protein. 41112970 β†—
Review MnFLS
Morus notabilis
dihydrokaempferol β†’ kaempferol non-CYP auxiliary enzyme (pathway partner, not cytochrome P450) ation; ation; MnFLS overexpression in Arabidopsis fls mutant restores kaempferol accumulation; in vivo transgenic experiment. 41112970 β†—
Review CHI
Camellia sinensis
naringenin chalcone β†’ naringenin non-CYP auxiliary enzyme (pathway partner, not cytochrome P450) ization; ization; Overexpression in tea plants confirmed role in flavonoid accumulation and drought tolerance; CHI is a non-P450 enzyme. 41104800 β†—
Review CHS
Camellia sinensis
4-coumaroyl-CoA β†’ naringenin chalcone non-CYP auxiliary enzyme (pathway partner, not cytochrome P450) Other; Other; Overexpression in tea plants confirmed role in flavonoid accumulation and drought tolerance; CHS is a non-P450 enzyme, but included per rules for… 41104800 β†—
Review FLS
Camellia sinensis
dihydrokaempferol β†’ kaempferol non-CYP auxiliary enzyme (pathway partner, not cytochrome P450) ation; ation; Overexpression in tea plants confirmed role in flavonoid accumulation and drought tolerance; FLS is a non-P450 enzyme. 41104800 β†—
Review NsOSC2
Neopicrorhiza scrophulariiflora
2,3-oxidosqualene β†’ Ξ²-amyrin non-CYP auxiliary enzyme (pathway partner, not cytochrome P450) ization; ization; Heterologous expression in yeast GIL77; GC-MS confirmed product. 40431127 β†—
Review NsOSC2
Neopicrorhiza scrophulariiflora
2,3-oxidosqualene β†’ Ξ±-amyrin non-CYP auxiliary enzyme (pathway partner, not cytochrome P450) ization; ization; Heterologous expression in yeast GIL77; GC-MS confirmed product. 40431127 β†—
Review VzTPS9
Vetiveria zizanioides
farnesyl pyrophosphate β†’ cedrol non-CYP auxiliary enzyme (pathway partner, not cytochrome P450) ization; ization; VzTPS9 is a terpene synthase, not a CYP450; however, the instruction requires output only for CYP450 enzymes. This reaction is included per t… 40324074 β†—
Review UGT79G15
Yang et
osmanthuside B β†’ rhamnosylated osmanthuside B non-CYP auxiliary enzyme (pathway partner, not cytochrome P450) ation; ation; Yang et al. 2023; UGT79G15 from Rehmannia glutinosa, in vitro assay. 40115775 β†—
Review UGT85AF10
Fuji et
hydroxytyrosol β†’ hydroxytyrosol 1-O-glucoside non-CYP auxiliary enzyme (pathway partner, not cytochrome P450) ation; ation; Fuji et al. 2023; recombinant UGT from Sesamum indicum, in vitro assay. 40115775 β†—
Review UGT85AF11
Fuji et
tyrosol β†’ salidroside non-CYP auxiliary enzyme (pathway partner, not cytochrome P450) ation; ation; Fuji et al. 2023; recombinant UGT from Sesamum indicum, in vitro assay. 40115775 β†—
Review UGT85AF8
Yang et
salidroside β†’ osmanthuside B non-CYP auxiliary enzyme (pathway partner, not cytochrome P450) ation; ation; Yang et al. 2023; UGT85AF8 from Ligustrum robustum, in vitro assay. 40115775 β†—
Review FLS
Arabidopsis thaliana
dihydrokaempferol β†’ kaempferol non-CYP auxiliary enzyme (pathway partner, not cytochrome P450) ation; ation; FLS from Arabidopsis thaliana (AT5G08640) expressed in Yarrowia lipolytica; conversion of dihydrokaempferol to kaempferol confirmed by HPLC and L… 39841399 β†—
Review UGT71C4
Gossypium hirsutum
naringenin β†’ naringenin-7-O-glucoside non-CYP auxiliary enzyme (pathway partner, not cytochrome P450) ation; ation; Recombinant UGT71C4 protein was purified and in vitro binding assays performed; HPLC/UPLC-ESI-MS analysis confirmed conversion of naringenin to n… 38689494 β†—
Review AsCPS
Arthrinium sacchari
geranylgeranyl diphosphate β†’ copalyl diphosphate non-CYP auxiliary enzyme (pathway partner, not cytochrome P450) ization; ization; AsCPS is a class II terpene cyclase from the fungus Arthrinium sacchari. The stereochemistry of CPP requires further verification. 38590534 β†—
Review NNMT
Rauvolfia serpentina
norajmaline β†’ ajmaline non-CYP auxiliary enzyme (pathway partner, not cytochrome P450) Other; Other; In vitro assay with purified His-tagged NNMT from E. coli; also in vivo in yeast. 38212296 β†—
Review FLS
Morus alba
dihydrokaempferol β†’ kaempferol non-CYP auxiliary enzyme (pathway partner, not cytochrome P450) ation; ation; FLS reduces dihydrokaempferol to kaempferol. 38014901 β†—
Review FLS
Morus alba
dihydroquercetin β†’ quercetin non-CYP auxiliary enzyme (pathway partner, not cytochrome P450) ation; ation; FLS reduces dihydroquercetin to quercetin. 38014901 β†—
Review UGT78D1
Morus alba
quercetin 3-O-glucoside β†’ rutin non-CYP auxiliary enzyme (pathway partner, not cytochrome P450) ation; ation; MaUGT78D1 is a flavonol-3-O-glucoside-L-rhamnosyltransferase; speculated to be involved in rutin biosynthesis. 38014901 β†—
Review OMT
Reinventing metabolic
TRIBOA-Glc β†’ DIMBOA-Glc non-CYP auxiliary enzyme (pathway partner, not cytochrome P450) Other; Other; AsBX7 from Aphelandra squarrosa methylates TRIBOA-Glc to DIMBOA-Glc, demonstrated in vitro and in N. benthamiana. 37812727 β†—
Review UGT85
Reinventing metabolic
2,4-dihydroxy-1,4-benzoxazin-3-… β†’ DIBOA-Glc non-CYP auxiliary enzyme (pathway partner, not cytochrome P450) ation; ation; LgBX8 from Lamium galeobdolon glucosylates DIBOA to DIBOA-Glc, demonstrated in vitro with purified enzyme and in N. benthamiana. 37812727 β†—
Review HmFLS1
Hypericum monogynum
dihydrokaempferol β†’ kaempferol non-CYP auxiliary enzyme (pathway partner, not cytochrome P450) ation; ation; In vitro and in vivo (with cofactors) conversion. 37727703 β†—
Review HmFLS1
Hypericum monogynum
dihydroquercetin β†’ quercetin non-CYP auxiliary enzyme (pathway partner, not cytochrome P450) ation; ation; In vitro and in vivo (with cofactors) conversion. 37727703 β†—
Review HmFLS1
Hypericum monogynum
naringenin β†’ kaempferol non-CYP auxiliary enzyme (pathway partner, not cytochrome P450) ation; ation; In vitro and in vivo (with cofactors) conversion; also produces apigenin. 37727703 β†—
Review HmFLS1
Hypericum monogynum
naringenin β†’ apigenin non-CYP auxiliary enzyme (pathway partner, not cytochrome P450) ation; ation; In vitro with cofactors; also produces kaempferol. 37727703 β†—
Review HmFLS1
Hypericum monogynum
eriodictyol β†’ quercetin non-CYP auxiliary enzyme (pathway partner, not cytochrome P450) ation; ation; In vitro with cofactors; also produces luteolin. 37727703 β†—
Review HmFLS1
Hypericum monogynum
eriodictyol β†’ luteolin non-CYP auxiliary enzyme (pathway partner, not cytochrome P450) ation; ation; In vitro with cofactors; also produces quercetin. 37727703 β†—
Review HmFLS2
Hypericum monogynum
dihydrokaempferol β†’ kaempferol non-CYP auxiliary enzyme (pathway partner, not cytochrome P450) ation; ation; In vitro with cofactors; in vivo small amounts. 37727703 β†—
Review HmFLS2
Hypericum monogynum
dihydroquercetin β†’ quercetin non-CYP auxiliary enzyme (pathway partner, not cytochrome P450) ation; ation; In vitro with cofactors; in vivo small amounts. 37727703 β†—
Review HmFLS2
Hypericum monogynum
naringenin β†’ kaempferol non-CYP auxiliary enzyme (pathway partner, not cytochrome P450) ation; ation; In vitro with cofactors; also produces apigenin. 37727703 β†—
Review HmFLS2
Hypericum monogynum
naringenin β†’ apigenin non-CYP auxiliary enzyme (pathway partner, not cytochrome P450) ation; ation; In vitro with cofactors; also produces kaempferol. 37727703 β†—