PAL

NEEDS_SALVAGE

Substrate reaction site Product reaction site MCS substructure diff highlighting · RDKit atom mapping

Substrate

L-phenylalanine

PubChem ↗ C1=CC=C(C=C1)C[C@@H](C(=O)O)N

PAL

ΔMass: -17.0265 Da mismatch

Product

cinnamic acid

PubChem ↗ C1=CC=C(C=C1)/C=C/C(=O)O

Evidence trail

Excerpts are machine-extracted plain text for biochemical provenance. Follow DOI / PubMed links for the primary literature; publisher figures and PDF images are not displayed here.

Source text excerpt ation; ation; Heterologous expression in S. cerevisiae; p-HCA production confirmed via HPLC and HRMS.

Reaction & quality gates

Mechanism: C-C / C-N cleavage (Dealkylation)
Evidence type: In vivo
Confidence: High
Data tier: Quarantine
non-CYP auxiliary enzyme (pathway partner, not cytochrome P450)
Substrate class: Other
Product class: Phenylpropanoids

Literature & public identifiers

PubMed: PMID:42038009 ↗
DOI: 10.1016/j.bidere.2026.100071 ↗
UniProt: A0A1S2X8N9 ↗
GenBank: —
NCBI TaxID: —

<i>De novo</i> biosynthesis of medicarpin in metabolically engineered yeast.