CwTPS8

Curcuma wenyujin

Zingiberaceae

Substrate reaction site Product reaction site MCS substructure diff highlighting · RDKit atom mapping

Substrate

farnesyl pyrophosphate

PubChem ↗ CC(=CCC/C(=C/CC/C(=C/COP(=O)(O)OP(=O)(O)O)/C)/C)C

CwTPS8

ΔMass: -177.9432 Da mismatch

Product

alpha-humulene

PubChem ↗ C/C/1=C\CC(/C=C/C/C(=C/CC1)/C)(C)C

Evidence trail

Excerpts are machine-extracted plain text for biochemical provenance. Follow DOI / PubMed links for the primary literature; publisher figures and PDF images are not displayed here.

Source text excerpt ization; ization; In vitro enzyme assay with purified recombinant CwTPS8 and FPP; GC-MS confirmed alpha-humulene as a major product.

Reaction & quality gates

Mechanism: Cyclization
Evidence type: In vitro
Confidence: High
Data tier: Quarantine
non-CYP auxiliary enzyme (pathway partner, not cytochrome P450)
Substrate class: Other
Product class: Other

Literature & public identifiers

PubMed: PMID:41114138 ↗
DOI: 10.3389/fpls.2025.1635141 ↗
UniProt: —
GenBank: PV682578 ↗
NCBI TaxID: 136221 ↗

Characterization of a sesquiterpene synthase and a short-chain dehydrogenase in zerumbone biosynthesis and the applications in engineered <i>Saccharomyces cerevisiae</i>.

Evidence trail

Reaction & quality gates

Literature & public identifiers

Other reactions by this enzyme