ODMT

Glycyrrhiza glabra

Fabaceae

Substrate reaction site Product reaction site MCS substructure diff highlighting · RDKit atom mapping

Substrate

medicarpin

PubChem ↗ COC1=CC2=C(C=C1)[C@@H]3COC4=C([C@@H]3O2)C=CC(=C4)O

ODMT

ΔMass: -14.0157 Da demethylation(-14.0157)

Product

demethylmedicarpin

PubChem ↗ C1[C@@H]2[C@H](C3=C(O1)C=C(C=C3)O)OC4=C2C=CC(=C4)O

Evidence trail

Excerpts are machine-extracted plain text for biochemical provenance. Follow DOI / PubMed links for the primary literature; publisher figures and PDF images are not displayed here.

Source text excerpt ation; ation; PMID 41782076, in vitro assay with recombinant GgODMT, O-demethylation of 4'-OCH3 to 4'-OH.

Reaction & quality gates

Mechanism: Demethylation (-14.01 Da)
Evidence type: In vitro
Confidence: High
Data tier: Quarantine
non-CYP auxiliary enzyme (pathway partner, not cytochrome P450)
Substrate class: Other
Product class: Other

Literature & public identifiers

PubMed: PMID:41782076 ↗
DOI: 10.1186/s43897-025-00202-x ↗
UniProt: —
GenBank: —
NCBI TaxID: 49827 ↗

Seizing the key nodes in glabridin biosynthesis network: identification of enzymes for producing licorice hairy roots with high levels of glabridin.

Evidence trail

Reaction & quality gates

Literature & public identifiers

Other reactions by this enzyme