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Quarantine mismatch Demethylation

ODMT

Glycyrrhiza glabra

Fabaceae

Substrate reaction site Product reaction site MCS substructure diff highlighting · RDKit atom mapping
Substrate
vestitone
PubChem ↗ COC1=CC(=C(C=C1)[C@@H]2COC3=C(C2=O)C=CC(=C3)O)O
ODMT
ΔMass: -16.0313 Da mismatch
Product
2'-hydroxydaidzein
PubChem ↗ C1=CC(=C(C=C1O)O)C2=COC3=C(C2=O)C=CC(=C3)O

Evidence trail

Excerpts are machine-extracted plain text for biochemical provenance. Follow DOI / PubMed links for the primary literature; publisher figures and PDF images are not displayed here.

Source text excerpt ation; ation; PMID 41782076, in vitro assay with recombinant GgODMT, O-demethylation of 4'-OCH3 to 4'-OH.

Reaction & quality gates

Mechanism
Demethylation
Evidence type
In vitro
Confidence
High
Data tier
Quarantine
non-CYP auxiliary enzyme (pathway partner, not cytochrome P450)
Substrate class
Other
Product class
Other

Literature & public identifiers

PubMed
PMID:41782076 ↗
DOI
10.1186/s43897-025-00202-x ↗
UniProt
GenBank
NCBI TaxID
49827 ↗

Seizing the key nodes in glabridin biosynthesis network: identification of enzymes for producing licorice hairy roots with high levels of glabridin.