NNMT

Rauvolfia serpentina

Apocynaceae

Substrate reaction site Product reaction site MCS substructure diff highlighting · RDKit atom mapping

Substrate

norajmaline

PubChem ↗ CC[C@H]1[C@@H]2C[C@H]3[C@H]4[C@@]5(C[C@@H]([C@H]2[C@H]5O)N3[C@@…

NNMT

ΔMass: +14.0157 Da mismatch

Product

ajmaline

PubChem ↗ CC[C@H]1[C@@H]2C[C@H]3[C@H]4[C@@]5(C[C@@H]([C@H]2[C@H]5O)N3[C@@…

Evidence trail

Excerpts are machine-extracted plain text for biochemical provenance. Follow DOI / PubMed links for the primary literature; publisher figures and PDF images are not displayed here.

Source text excerpt Other; Other; In vitro assay with purified His-tagged NNMT from E. coli; also in vivo in yeast.

Reaction & quality gates

Mechanism: Other
Evidence type: In vitro
Confidence: High
Data tier: Quarantine
non-CYP auxiliary enzyme (pathway partner, not cytochrome P450)
Substrate class: Other
Product class: Other

Literature & public identifiers

PubMed: PMID:38212296 ↗
DOI: 10.1038/s41467-024-44797-z ↗
UniProt: A0A075D6M1 ↗
GenBank: —
NCBI TaxID: 4060 ↗

De novo biosynthesis of antiarrhythmic alkaloid ajmaline.