PKS1

Unknown

Substrate reaction site Product reaction site MCS substructure diff highlighting · RDKit atom mapping

Substrate

3-methylorsellinic acid

PubChem ↗ CC1=CC(=C(C(=C1C(=O)O)O)C)O

PKS1

ΔMass: +164.0473 Da mismatch

Product

4-O-demethylbarbatic acid

PubChem ↗ CC1=CC(=C(C(=C1C(=O)OC2=C(C(=C(C(=C2)C)C(=O)O)O)C)O)C)O

Evidence trail

Excerpts are machine-extracted plain text for biochemical provenance. Follow DOI / PubMed links for the primary literature; publisher figures and PDF images are not displayed here.

Source text excerpt Other; Other; Heterologous expression of pks1s in Aspergillus oryzae NSAR1 produced 4-O-demethylbarbatic acid (PMID: 41225761).

Reaction & quality gates

Mechanism: Other
Evidence type: In vitro
Confidence: High
Data tier: Quarantine
non-CYP auxiliary enzyme (pathway partner, not cytochrome P450)
Substrate class: Organic acids
Product class: Organic acids

Literature & public identifiers

PubMed: PMID:41225761 ↗
DOI: 10.1111/nph.70731 ↗
UniProt: PV482831 ↗
GenBank: PV482831 ↗
NCBI TaxID: —

Deciphering the biosynthetic pathways of lichen acids.