CYP450

Iterative cascade CYP450

Substrate reaction site Product reaction site MCS substructure diff highlighting · RDKit atom mapping

Substrate

β-amyrin

PubChem ↗ [H][C@]12[C@H](O)C=C3[C@]4([H])CC(C)(C)CC[C@]4(C)CC[C@@]3(C)[C@…

CYP450

ΔMass: +43.9534 Da mismatch

Product

quillaic acid

PubChem ↗ C[C@]12CC[C@@H]([C@@]([C@@H]1CC[C@@]3([C@@H]2CC=C4[C@]3(C[C@H](…

Evidence trail

Excerpts are machine-extracted plain text for biochemical provenance. Follow DOI / PubMed links for the primary literature; publisher figures and PDF images are not displayed here.

Source text excerpt ation; 模糊酶名已剔除: CYP450; ation; 原文酶字段: CYP450 (quininic acid oxidase); Iterative cascade of CYP450 oxidations converting β-amyrin to quillaic acid in engineered S. cerevisiae (PMID 38720067). Source organism Quillaja saponaria mentioned but not in Abstract/Methods with Latin binomial; set to NEEDS_SALVAGE.; schema_validation_failed; schema_validation_failed

Reaction & quality gates

Mechanism: Oxidation
Evidence type: In vivo
Confidence: Needs_review
Data tier: Quarantine
vague_enzyme
Substrate class: Terpenoids
Product class: Organic acids

Literature & public identifiers

PubMed: PMID:41161185 ↗
DOI: 10.1016/j.copbio.2025.103374 ↗
UniProt: —
GenBank: —
NCBI TaxID: —

Advances in the microbial biosynthesis of therapeutic terpenoids.