CYP725A37

Taxus brevifolia CYP725A

Taxaceae

Substrate reaction site Product reaction site MCS substructure diff highlighting · RDKit atom mapping

Substrate

5α,13α-diacetoxytaxa-4(20),11(12)-diene-10β-ol

PubChem ↗ Crowdsource substrate structure

CYP725A37

ΔMass: no_smiles Missing dual SMILES or RDKit not validated

Product

9,10-deacetyltaxusin

PubChem ↗ Crowdsource product structure

Evidence trail

Excerpts are machine-extracted plain text for biochemical provenance. Follow DOI / PubMed links for the primary literature; publisher figures and PDF images are not displayed here.

Source text excerpt ation; ation; CYP725A37 catalyzes C9 hydroxylation of 10 to form 11; confirmed by in vivo and in vitro assays with S. cerevisiae expressing CYP725A37 and TCPR.

Reaction & quality gates

Mechanism: Hydroxylation
Evidence type: In vitro
Confidence: High
Data tier: Silver
mass=no_smiles; incomplete_SMILES
Substrate class: Other
Product class: Other

Literature & public identifiers

PubMed: PMID:38490987 ↗
DOI: 10.1038/s41467-024-46583-3 ↗
UniProt: —
GenBank: —
NCBI TaxID: 46220 ↗

Biosynthesis of the highly oxygenated tetracyclic core skeleton of Taxol.