CYP71

Catharanthus roseus

Apocynaceae

Substrate reaction site Product reaction site MCS substructure diff highlighting · RDKit atom mapping

Substrate

19E-geissoschizine

PubChem ↗ C/C=C\1/CN2CCC3=C([C@@H]2C[C@@H]1/C(=C/O)/C(=O)OC)NC4=CC=CC=C34

CYP71

ΔMass: -2.0157 Da ketone_formation(-2.0157)

Product

rhazimal

PubChem ↗ C/C=C\1/CN2CC[C@@]34C5=CC=CC=C5N=C3[C@@H]2C[C@@H]1[C@@]4(C=O)C(…

Evidence trail

Excerpts are machine-extracted plain text for biochemical provenance. Follow DOI / PubMed links for the primary literature; publisher figures and PDF images are not displayed here.

Source text excerpt ation; ation; CrRS (rhazimal synthase) catalyzes C7-C16 oxidative coupling; rhazimal spontaneously deformylates to strictamine.

Reaction & quality gates

Mechanism: Ketone formation (-2.02 Da)
Evidence type: In vitro
Confidence: High
Data tier: Gold
Latin binomial + experiment + dual SMILES + ΔMass pass
Substrate class: Other
Product class: Other

Literature & public identifiers

PubMed: PMID:40202182 ↗
DOI: 10.1002/anie.202501323 ↗
UniProt: W8JDE2 ↗
GenBank: —
NCBI TaxID: 4058 ↗

Oxidative Rearrangements of the Alkaloid Intermediate Geissoschizine.

Evidence trail

Reaction & quality gates

Literature & public identifiers

Other reactions by this enzyme