AtC4H

Enhanced chlorogenic

Substrate reaction site Product reaction site MCS substructure diff highlighting · RDKit atom mapping

Substrate

cinnamic acid

PubChem ↗ C1=CC=C(C=C1)/C=C/C(=O)O

AtC4H

ΔMass: +15.9949 Da hydroxylation(+15.9949)

Product

p-coumaric acid

PubChem ↗ C1=CC(=CC=C1/C=C/C(=O)O)O

Evidence trail

Excerpts are machine-extracted plain text for biochemical provenance. Follow DOI / PubMed links for the primary literature; publisher figures and PDF images are not displayed here.

Source text excerpt ation; ation; Fusion expression of AtC4H and At4CL1 in S. cerevisiae improved CGA production; AtC4H is a plant P450 (cinnamate-4-hydroxylase) from Arabidopsis thaliana.

Reaction & quality gates

Mechanism: Hydroxylation (+15.99 Da)
Evidence type: In vivo
Confidence: High
Data tier: Gold
Latin binomial + experiment + dual SMILES + ΔMass pass
Substrate class: Phenylpropanoids
Product class: Phenylpropanoids

Literature & public identifiers

PubMed: PMID:40248482 ↗
DOI: 10.1016/j.synbio.2025.03.004 ↗
UniProt: —
GenBank: —
NCBI TaxID: —

Enhanced chlorogenic acid production from glucose via systematic metabolic engineering of <i>Saccharomyces cerevisiae</i>.