CYP76AD6

Multiple transitions CYP76A

Substrate reaction site Product reaction site MCS substructure diff highlighting · RDKit atom mapping

Substrate

tyrosine

PubChem ↗ C1=CC(=CC=C1C[C@@H](C(=O)O)N)O

CYP76AD6

ΔMass: +15.9949 Da hydroxylation(+15.9949)

Product

L-DOPA

PubChem ↗ C1=CC(=C(C=C1C[C@@H](C(=O)O)N)O)O

Evidence trail

Excerpts are machine-extracted plain text for biochemical provenance. Follow DOI / PubMed links for the primary literature; publisher figures and PDF images are not displayed here.

Source text excerpt ation; ation; CYP76AD6 from Beta vulgaris (GenBank OQ362268.1) hydroxylates tyrosine to L-DOPA; used in yeast heterologous assays to provide substrate for DODA activity measurement.

Reaction & quality gates

Mechanism: Hydroxylation (+15.99 Da)
Evidence type: In vivo
Confidence: High
Data tier: Gold
Latin binomial + experiment + dual SMILES + ΔMass pass
Substrate class: Other
Product class: Other

Literature & public identifiers

PubMed: PMID:40325884 ↗
DOI: 10.1111/nph.70177 ↗
UniProt: OQ362268 ↗
GenBank: OQ362268 ↗
NCBI TaxID: —

Multiple transitions to high l-DOPA 4,5-dioxygenase activity reveal molecular pathways to convergent betalain pigmentation in Caryophyllales.