CYP76AH1

Salvia miltiorrhiza CYP76A

Lamiaceae

Substrate reaction site Product reaction site MCS substructure diff highlighting · RDKit atom mapping

Substrate

miltiradiene

PubChem ↗ CC(C)C1=CCC2=C(C1)CC[C@@H]3[C@@]2(CCCC3(C)C)C

CYP76AH1

ΔMass: +13.9793 Da mismatch

Product

ferruginol

PubChem ↗ CC(C)C1=C(C=C2C(=C1)CC[C@@H]3[C@@]2(CCCC3(C)C)C)O

Evidence trail

Excerpts are machine-extracted plain text for biochemical provenance. Follow DOI / PubMed links for the primary literature; publisher figures and PDF images are not displayed here.

Source text excerpt ation; ation; Based on reference [12] cited in the text; SmCYP76AH1 is a cytochrome P450 involved in tanshinone biosynthesis, converting miltiradiene to ferruginol.

Reaction & quality gates

Mechanism: Hydroxylation
Evidence type: In vivo
Confidence: High
Data tier: Silver
mass=mismatch
Substrate class: Terpenoids
Product class: Other

Literature & public identifiers

PubMed: PMID:40391389 ↗
DOI: 10.1093/hr/uhaf096 ↗
UniProt: JX422213 ↗
GenBank: JX422213 ↗
NCBI TaxID: 226208 ↗

The SmWRKY32-SmbHLH65/SmbHLH85 regulatory module mediates tanshinone biosynthesis in <i>Salvia miltiorrhiza</i>.

Evidence trail

Reaction & quality gates

Literature & public identifiers

Other reactions by this enzyme