CYP71AV1

Source organism CYP71A

Substrate reaction site Product reaction site MCS substructure diff highlighting · RDKit atom mapping

Substrate

amorphadiene

PubChem ↗ C[C@@H]1CC[C@H]([C@@H]2[C@H]1CCC(=C2)C)C(=C)C

CYP71AV1

ΔMass: +29.9742 Da methyl_to_carboxyl(+29.9742)

Product

artemisinic acid

PubChem ↗ C[C@@H]1CC[C@H]([C@@H]2[C@H]1CCC(=C2)C)C(=C)C(=O)O

Evidence trail

Excerpts are machine-extracted plain text for biochemical provenance. Follow DOI / PubMed links for the primary literature; publisher figures and PDF images are not displayed here.

Source text excerpt ation; ation; Three-step oxidation of amorphadiene to artemisinic acid by CYP71AV1 and CPR in engineered S. cerevisiae (PMID 16612385, 23575629). Source organism Artemisia annua is mentioned in text but not in Abstract/Methods with Latin binomial; set to NEEDS_SALVAGE.

Reaction & quality gates

Mechanism: Oxidation
Evidence type: In vivo
Confidence: High
Data tier: Gold
Latin binomial + experiment + dual SMILES + ΔMass pass
Substrate class: Other
Product class: Organic acids

Literature & public identifiers

PubMed: PMID:41161185 ↗
DOI: 10.1016/j.copbio.2025.103374 ↗
UniProt: H6VZA6 ↗
GenBank: —
NCBI TaxID: —

Advances in the microbial biosynthesis of therapeutic terpenoids.