KwwB

Kitasatospora sp

Substrate reaction site Product reaction site MCS substructure diff highlighting · RDKit atom mapping

Substrate

KwwA precursor peptide (WFW motif)

PubChem ↗ Crowdsource substrate structure

KwwB

ΔMass: no_smiles Missing dual SMILES or RDKit not validated

Product

Trp-C5-Trp-N1 cross-linked peptide

PubChem ↗ Crowdsource product structure

Evidence trail

Excerpts are machine-extracted plain text for biochemical provenance. Follow DOI / PubMed links for the primary literature; publisher figures and PDF images are not displayed here.

Source text excerpt Other; Other; KwwB from Kitasatospora sp. GAS204B catalyzes cross-linking between Trp-C5 and Trp-N1 on the WxW motif of precursor peptide KwwA, confirmed by NMR and MS/MS. Enzyme source is bacterial, not plant; source_organism set to NEEDS_SALVAGE per rule 3.

Reaction & quality gates

Mechanism: Other
Evidence type: In vivo
Confidence: High
Data tier: Silver
mass=no_smiles; incomplete_SMILES
Substrate class: Other
Product class: Other

Literature & public identifiers

PubMed: PMID:41448579 ↗
DOI: 10.1021/acs.orglett.5c04848 ↗
UniProt: —
GenBank: —
NCBI TaxID: —

P450 Cyptide Synthase KwwB Catalyzes Trp-C5-Trp-N1 Cross-Linking and Accepts Diverse Precursor Peptides.