CYP719B1

Biosynthesis of CYP719B

Substrate reaction site Product reaction site MCS substructure diff highlighting · RDKit atom mapping

Substrate

(R)-reticuline

PubChem ↗ CN1CCC2=CC(=C(C=C2[C@H]1CC3=CC(=C(C=C3)OC)O)O)OC

CYP719B1

ΔMass: -2.0157 Da fallback:~-2 Da (成酮/脱氢)

Product

salutaridine

PubChem ↗ CN1CC[C@]23C=C(C(=O)C=C2[C@H]1CC4=C3C(=C(C=C4)OC)O)OC

Evidence trail

Excerpts are machine-extracted plain text for biochemical provenance. Follow DOI / PubMed links for the primary literature; publisher figures and PDF images are not displayed here.

Source text excerpt ization; ization; PMID=41776991, 正文第5页: 'PsCYP719B1 in opium poppy stereospecifically converts (R)-reticuline into salutaridine through C2′–C4a coupling'。

Reaction & quality gates

Mechanism: Ketone formation (-2.02 Da)
Evidence type: In vitro
Confidence: High
Data tier: Gold
Latin binomial + experiment + dual SMILES + ΔMass pass
Substrate class: Other
Product class: Other

Literature & public identifiers

PubMed: PMID:41776991 ↗
DOI: 10.1016/j.xplc.2026.101786 ↗
UniProt: B1NF18 ↗
GenBank: —
NCBI TaxID: —

Biosynthesis of benzylisoquinoline alkaloids and its evolution in plants.