CYP719A3

Biosynthesis of CYP719A

Substrate reaction site Product reaction site MCS substructure diff highlighting · RDKit atom mapping

Substrate

(S)-scoulerine

PubChem ↗ COC1=C(C2=C(C[C@H]3C4=CC(=C(C=C4CCN3C2)OC)O)C=C1)O

CYP719A3

ΔMass: -2.0157 Da fallback:~-2 Da (成酮/脱氢)

Product

(S)-nandinine

PubChem ↗ COC1=C(C2=C(C[C@H]3C4=CC5=C(C=C4CCN3C2)OCO5)C=C1)O

Evidence trail

Excerpts are machine-extracted plain text for biochemical provenance. Follow DOI / PubMed links for the primary literature; publisher figures and PDF images are not displayed here.

Source text excerpt ization; ization; PMID=41776991, 正文第8页: 'EcCYP719A3 from E. californica converts (S)-scoulerine into (S)-nandinine via C2–C3 bridge formation'。

Reaction & quality gates

Mechanism: Ketone formation (-2.02 Da)
Evidence type: In vitro
Confidence: High
Data tier: Gold
Latin binomial + experiment + dual SMILES + ΔMass pass
Substrate class: Other
Product class: Other

Literature & public identifiers

PubMed: PMID:41776991 ↗
DOI: 10.1016/j.xplc.2026.101786 ↗
UniProt: Q50LH4 ↗
GenBank: —
NCBI TaxID: —

Biosynthesis of benzylisoquinoline alkaloids and its evolution in plants.