CYP719A1

Biosynthesis of CYP719A

Substrate reaction site Product reaction site MCS substructure diff highlighting · RDKit atom mapping

Substrate

(S)-tetrahydrocolumbamine

PubChem ↗ COC1=C(C2=C(C[C@H]3C4=CC(=C(C=C4CCN3C2)OC)O)C=C1)OC

CYP719A1

ΔMass: -2.0157 Da fallback:~-2 Da (成酮/脱氢)

Product

(S)-canadine

PubChem ↗ COC1=C(C2=C(C[C@H]3C4=CC5=C(C=C4CCN3C2)OCO5)C=C1)OC

Evidence trail

Excerpts are machine-extracted plain text for biochemical provenance. Follow DOI / PubMed links for the primary literature; publisher figures and PDF images are not displayed here.

Source text excerpt ization; ization; PMID=41776991, 正文第8页: 'CcCYP719A1 from C. chinensis catalyzes methylenedioxy bridge formation at C2–C3 or C9–C10'。

Reaction & quality gates

Mechanism: Ketone formation (-2.02 Da)
Evidence type: In vitro
Confidence: High
Data tier: Gold
Latin binomial + experiment + dual SMILES + ΔMass pass
Substrate class: Other
Product class: Other

Literature & public identifiers

PubMed: PMID:41776991 ↗
DOI: 10.1016/j.xplc.2026.101786 ↗
UniProt: Q948Y1 ↗
GenBank: —
NCBI TaxID: —

Biosynthesis of benzylisoquinoline alkaloids and its evolution in plants.