CYP728D26

Salvia divinorum CYP728D

Lamiaceae

Substrate reaction site Product reaction site MCS substructure diff highlighting · RDKit atom mapping

Substrate

annonene

PubChem ↗ Crowdsource substrate structure

CYP728D26

ΔMass: no_smiles Missing dual SMILES or RDKit not validated

Product

hardwickiic acid

PubChem ↗ C[C@@H]1CC[C@@]2([C@@H]([C@]1(C)CCC3=COC=C3)CCC=C2C(=O)O)C

Evidence trail

Excerpts are machine-extracted plain text for biochemical provenance. Follow DOI / PubMed links for the primary literature; publisher figures and PDF images are not displayed here.

Source text excerpt ation; ation; Also known as hardwickiic acid synthase (SdHDAS).

Reaction & quality gates

Mechanism: Oxidation
Evidence type: In vivo
Confidence: High
Data tier: Silver
mass=no_smiles; incomplete_SMILES
Substrate class: Other
Product class: Organic acids

Literature & public identifiers

PubMed: PMID:41872198 ↗
DOI: 10.1038/s41467-026-70885-3 ↗
UniProt: A0A8E4JAU4 ↗
GenBank: —
NCBI TaxID: 28513 ↗

Comparative genome analysis provides a foundation for defining salvinorin A biosynthesis in Salvia divinorum.

Evidence trail

Reaction & quality gates

Literature & public identifiers

Other reactions by this enzyme