Tpm16

Based on

Substrate reaction site Product reaction site MCS substructure diff highlighting · RDKit atom mapping

Substrate

tropansamycin precursor a

PubChem ↗ Crowdsource substrate structure

Tpm16

ΔMass: no_smiles Missing dual SMILES or RDKit not validated

Product

tropansamycin C (3)

PubChem ↗ Crowdsource product structure

Evidence trail

Excerpts are machine-extracted plain text for biochemical provenance. Follow DOI / PubMed links for the primary literature; publisher figures and PDF images are not displayed here.

Source text excerpt ation; ation; CYP450 Tpm16 epoxidizes C9/C10 double bond of precursor a to form intermediate b, which leads to 3. Based on gene deletion mutant Δtpm16 and proposed pathway.

Reaction & quality gates

Mechanism: Epoxidation
Evidence type: In vivo
Confidence: High
Data tier: Silver
mass=no_smiles; incomplete_SMILES
Substrate class: Other
Product class: Other

Literature & public identifiers

PubMed: PMID:41983063 ↗
DOI: 10.1016/j.engmic.2026.100263 ↗
UniProt: —
GenBank: —
NCBI TaxID: —

Genome-guided discovery of tropansamycins: antimicrobial pentaketide ansamycins.