CYP719A1

Coptis japonica CYP719A

Ranunculaceae

Substrate reaction site Product reaction site MCS substructure diff highlighting · RDKit atom mapping

Substrate

(S)-7a

PubChem ↗ Crowdsource substrate structure

CYP719A1

ΔMass: no_smiles Missing dual SMILES or RDKit not validated

Product

(S)-canadine

PubChem ↗ COC1=C(C2=C(C[C@H]3C4=CC5=C(C=C4CCN3C2)OCO5)C=C1)OC

Evidence trail

Excerpts are machine-extracted plain text for biochemical provenance. Follow DOI / PubMed links for the primary literature; publisher figures and PDF images are not displayed here.

Source text excerpt ation; ation; CjCYP719A1 catalyzes methylenedioxy-bridge formation from (S)-7a to (S)-canadine; in vitro activity assays with purified enzyme lysate and NADPH cofactor.

Reaction & quality gates

Mechanism: Oxidation
Evidence type: In vitro
Confidence: High
Data tier: Silver
mass=no_smiles; incomplete_SMILES
Substrate class: Other
Product class: Other

Literature & public identifiers

PubMed: PMID:42063854 ↗
DOI: 10.1021/jacsau.6c00169 ↗
UniProt: Q948Y1 ↗
GenBank: —
NCBI TaxID: 3442 ↗

Engineering Plant-Derived P450 Enables the Efficient Production of Berberine through a Concise and Modular Enzymatic Cascade in <i>E. coli</i>.