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Quarantine mismatch Other

NBS

Narcissus pseudonarcissus

Amaryllidaceae

Substrate reaction site Product reaction site MCS substructure diff highlighting · RDKit atom mapping
Substrate
tyramine
PubChem ↗ C1=CC(=CC=C1CCN)O
NBS
ΔMass: +122.0368 Da mismatch
Product
norbelladine
PubChem ↗ C1=CC(=CC=C1CCNCC2=CC(=C(C=C2)O)O)O

Evidence trail

Excerpts are machine-extracted plain text for biochemical provenance. Follow DOI / PubMed links for the primary literature; publisher figures and PDF images are not displayed here.

Source text excerpt Other; Other; NpNBS catalyzes condensation of tyramine and 3,4-dihydroxybenzaldehyde to form norbelladine; reaction type is condensation (Mannich reaction), mapped to 'Other'.

Reaction & quality gates

Mechanism
Other
Evidence type
In vitro
Confidence
High
Data tier
Quarantine
non-CYP auxiliary enzyme (pathway partner, not cytochrome P450)
Substrate class
Other
Product class
Other

Literature & public identifiers

PubMed
PMID:30526483 ↗
DOI
10.1186/s12870-018-1570-4 ↗
UniProt
A0A3G5BB24 ↗
GenBank
NCBI TaxID
39639 ↗

Cloning and characterization of norbelladine synthase catalyzing the first committed reaction in Amaryllidaceae alkaloid biosynthesis.