ABA2

Metabolic engineering

Substrate reaction site Product reaction site MCS substructure diff highlighting · RDKit atom mapping

Substrate

β-nootkatol

PubChem ↗ C[C@@H]1C[C@@H](C=C2[C@]1(C[C@@H](CC2)C(=C)C)C)O

ABA2

ΔMass: -2.0157 Da ketone_formation(-2.0157)

Product

(+)-nootkatone

PubChem ↗ C[C@@H]1CC(=O)C=C2[C@]1(C[C@@H](CC2)C(=C)C)C

Evidence trail

Excerpts are machine-extracted plain text for biochemical provenance. Follow DOI / PubMed links for the primary literature; publisher figures and PDF images are not displayed here.

Source text excerpt ation; ation; ABA2 from Citrus sinensis; SDR family dehydrogenase; overexpression in S. cerevisiae increased yield to 53.48 mg/L.

Reaction & quality gates

Mechanism: Ketone formation (-2.02 Da)
Evidence type: In vivo
Confidence: High
Data tier: Gold
Latin binomial + experiment + dual SMILES + ΔMass pass
Substrate class: Other
Product class: Other

Literature & public identifiers

PubMed: PMID:32013959 ↗
DOI: —
UniProt: HM036684 ↗
GenBank: HM036684 ↗
NCBI TaxID: —

Metabolic engineering Saccharomyces cerevisiae for de novo production of the sesquiterpenoid (+)-nootkatone.