LtmJ

Conversion of

Substrate reaction site Product reaction site MCS substructure diff highlighting · RDKit atom mapping

Substrate

terpendole E (5)

PubChem ↗ Crowdsource substrate structure

LtmJ

ΔMass: no_smiles Missing dual SMILES or RDKit not validated

Product

lolicine A (17)

PubChem ↗ Crowdsource product structure

Evidence trail

Excerpts are machine-extracted plain text for biochemical provenance. Follow DOI / PubMed links for the primary literature; publisher figures and PDF images are not displayed here.

Source text excerpt ation; ation; Conversion of 5 to 17 was extremely low; detected by MS.

Reaction & quality gates

Mechanism: Oxidation
Evidence type: In vivo
Confidence: Low
Data tier: Quarantine
non-CYP auxiliary enzyme (pathway partner, not cytochrome P450)
Substrate class: Other
Product class: Other

Literature & public identifiers

PubMed: PMID:32677206 ↗
DOI: 10.1002/anie.202007280 ↗
UniProt: —
GenBank: —
NCBI TaxID: —

Biosynthesis of Indole Diterpene Lolitrems: Radical-Induced Cyclization of an Epoxyalcohol Affording a Characteristic Lolitremane Skeleton.