CYP82X1

Papaver somniferum CYP82X

Papaveraceae

Substrate reaction site Product reaction site MCS substructure diff highlighting · RDKit atom mapping

Substrate

(S)-N-methylcanadine

PubChem ↗ C[N+]12CCC3=CC4=C(C=C3[C@@H]1CC5=C(C2)C(=C(C=C5)OC)OC)OCO4

CYP82X1

ΔMass: +58.9775 Da mismatch

Product

noscapine

PubChem ↗ CN1CCC2=CC3=C(C(=C2[C@@H]1[C@@H]4C5=C(C(=C(C=C5)OC)OC)C(=O)O4)O…

Evidence trail

Excerpts are machine-extracted plain text for biochemical provenance. Follow DOI / PubMed links for the primary literature; publisher figures and PDF images are not displayed here.

Source text excerpt ation; ation; CYP82X1 is involved in converting (S)-N-methylcanadine to noscapine; in vitro assays confirmed.

Reaction & quality gates

Mechanism: Hydroxylation
Evidence type: In vitro
Confidence: High
Data tier: Silver
mass=mismatch
Substrate class: Other
Product class: Other

Literature & public identifiers

PubMed: PMID:32685922 ↗
DOI: 10.1016/j.xplc.2020.100029 ↗
UniProt: I3V6B7 ↗
GenBank: —
NCBI TaxID: 3469 ↗

Over 100 Million Years of Enzyme Evolution Underpinning the Production of Morphine in the Papaveraceae Family of Flowering Plants.

Evidence trail

Reaction & quality gates

Literature & public identifiers

Other reactions by this enzyme