CYP71D411

Salvia miltiorrhiza CYP71D

Lamiaceae

Substrate reaction site Product reaction site MCS substructure diff highlighting · RDKit atom mapping

Substrate

sugiol

PubChem ↗ CC(C)C1=C(C=C2C(=C1)C(=O)C[C@@H]3[C@@]2(CCCC3(C)C)C)O

CYP71D411

ΔMass: no_smiles Missing dual SMILES or RDKit not validated

Product

20-hydroxysugiol

PubChem ↗ Crowdsource product structure

Evidence trail

Excerpts are machine-extracted plain text for biochemical provenance. Follow DOI / PubMed links for the primary literature; publisher figures and PDF images are not displayed here.

Source text excerpt ation; ation; CYP71D411 catalyzes C20 hydroxylation of sugiol (3) to 20-hydroxysugiol (12), confirmed by NMR after scaled-up reaction.

Reaction & quality gates

Mechanism: Hydroxylation
Evidence type: In vitro
Confidence: High
Data tier: Silver
mass=no_smiles; incomplete_SMILES
Substrate class: Other
Product class: Other

Literature & public identifiers

PubMed: PMID:33514704 ↗
DOI: 10.1038/s41467-021-20959-1 ↗
UniProt: A0A0B4VRH1 ↗
GenBank: —
NCBI TaxID: 226208 ↗

Expansion within the CYP71D subfamily drives the heterocyclization of tanshinones synthesis in Salvia miltiorrhiza.