T3O

Catharanthus roseus

Apocynaceae

Substrate reaction site Product reaction site MCS substructure diff highlighting · RDKit atom mapping

Substrate

tabersonine

PubChem ↗ CC[C@]12CC(=C3[C@@]4([C@H]1N(CC4)CC=C2)C5=CC=CC=C5N3)C(=O)OC

T3O

ΔMass: no_smiles Missing dual SMILES or RDKit not validated

Product

3-hydroxy-2,3-dihydrotabersonine

PubChem ↗ Crowdsource product structure

Evidence trail

Excerpts are machine-extracted plain text for biochemical provenance. Follow DOI / PubMed links for the primary literature; publisher figures and PDF images are not displayed here.

Source text excerpt ation; ation; Promiscuous activity of T3O on tabersonine leading to vindorosine by-product; detected in yeast.

Reaction & quality gates

Mechanism: Hydroxylation
Evidence type: In vitro
Confidence: Medium
Data tier: Silver
mass=no_smiles; incomplete_SMILES
Substrate class: Other
Product class: Other

Literature & public identifiers

PubMed: PMID:34531512 ↗
DOI: 10.1038/s42003-021-02617-w ↗
UniProt: I1TEM1 ↗
GenBank: —
NCBI TaxID: 4058 ↗

Efficient production of vindoline from tabersonine by metabolically engineered Saccharomyces cerevisiae.

Evidence trail

Reaction & quality gates

Literature & public identifiers

Other reactions by this enzyme