COS

Combinatorial transient

Substrate reaction site Product reaction site MCS substructure diff highlighting · RDKit atom mapping

Substrate

germacra-1(10),4,11(13)-trien-12-oic acid

PubChem ↗ C/C/1=C\CC/C(=C/C[C@@H](CC1)C(=C)C(=O)O)/C

COS

ΔMass: -2.0157 Da fallback:~-2 Da (成酮/脱氢)

Product

costunolide

PubChem ↗ C/C/1=C\CC/C(=C/[C@@H]2[C@@H](CC1)C(=C)C(=O)O2)/C

Evidence trail

Excerpts are machine-extracted plain text for biochemical provenance. Follow DOI / PubMed links for the primary literature; publisher figures and PDF images are not displayed here.

Source text excerpt Other; Other; COS is a suspected cytochrome P450 that hydroxylates germacra-1(10),4,11(13)-trien-12-oic acid at C6, followed by spontaneous cyclization to costunolide; evidence from agroinfiltration in N. benthamiana.

Reaction & quality gates

Mechanism: Ketone formation (-2.02 Da)
Evidence type: In vivo
Confidence: High
Data tier: Gold
Latin binomial + experiment + dual SMILES + ΔMass pass
Substrate class: Organic acids
Product class: Terpenoids

Literature & public identifiers

PubMed: PMID:36582649 ↗
DOI: 10.3389/fpls.2022.1034893 ↗
UniProt: HQ439599 ↗
GenBank: HQ439599 ↗
NCBI TaxID: —

Combinatorial transient gene expression strategies to enhance terpenoid production in plants.