T3R

Reductases of

Substrate reaction site Product reaction site MCS substructure diff highlighting · RDKit atom mapping

Substrate

tabersonine

PubChem ↗ CC[C@]12CC(=C3[C@@]4([C@H]1N(CC4)CC=C2)C5=CC=CC=C5N3)C(=O)OC

T3R

ΔMass: no_smiles Missing dual SMILES or RDKit not validated

Product

3-hydroxy-2,3-dihydrotabersonine

PubChem ↗ Crowdsource product structure

Evidence trail

Excerpts are machine-extracted plain text for biochemical provenance. Follow DOI / PubMed links for the primary literature; publisher figures and PDF images are not displayed here.

Source text excerpt ion; ion; CrT3R catalyzes 1,2-iminium reduction of tabersonine epoxide intermediate to 3-hydroxy-2,3-dihydrotabersonine.

Reaction & quality gates

Mechanism: Reduction
Evidence type: In vitro
Confidence: High
Data tier: Silver
mass=no_smiles; incomplete_SMILES
Substrate class: Other
Product class: Other

Literature & public identifiers

PubMed: PMID:40536199 ↗
DOI: 10.1021/acs.biochem.5c00234 ↗
UniProt: KP122966 ↗
GenBank: KP122966 ↗
NCBI TaxID: —

A Tight-Knit Family: The Medium-Chain Dehydrogenase/Reductases of Monoterpene Indole Alkaloid Biosynthesis.