CYP74A2

Parthenium argentatum CYP74A

Asteraceae

Substrate reaction site Product reaction site MCS substructure diff highlighting · RDKit atom mapping

Substrate

13(S)-hydroperoxy-9(Z),11(E)-octadecadienoic acid

PubChem ↗ CCCCC[C@@H](/C=C/C=C\CCCCCCCC(=O)O)OO

CYP74A2

ΔMass: Exempt atypical_cleavage_exempt

Product

allene oxide

PubChem ↗ C=C1CO1

Evidence trail

Excerpts are machine-extracted plain text for biochemical provenance. Follow DOI / PubMed links for the primary literature; publisher figures and PDF images are not displayed here.

Source text excerpt ation; ation; Crystal structure of AOS (CYP74A2) from guayule (Parthenium argentatum) with substrate analog; enzyme activity toward 13(S)-hydroperoxide confirmed in vitro.

Reaction & quality gates

Mechanism: Atypical_Cleavage (Hydroperoxide lyase)
Evidence type: In vitro
Confidence: High
Data tier: Special
Atypical P450 cleavage (CYP74); ΔMass exempt
Substrate class: Organic acids
Product class: Other

Literature & public identifiers

PubMed: PMID:18787124 ↗
DOI: 10.1073/pnas.0804099105 ↗
UniProt: Q40778 ↗
GenBank: —
NCBI TaxID: 35935 ↗

Modes of heme binding and substrate access for cytochrome P450 CYP74A revealed by crystal structures of allene oxide synthase.