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Silver no_smiles Hydroxylation

CYP76M8

Oryza sativa CYP76M

Poaceae

Substrate reaction site Product reaction site MCS substructure diff highlighting · RDKit atom mapping
Substrate
ent-isokaurene
PubChem ↗ CC1=C[C@@]23CC[C@H]4[C@]([C@@H]2CC[C@@H]1C3)(CCCC4(C)C)C
CYP76M8
ΔMass: no_smiles Missing dual SMILES or RDKit not validated
Product
7α-hydroxy-ent-isokaurene
PubChem ↗ Crowdsource product structure

Evidence trail

Excerpts are machine-extracted plain text for biochemical provenance. Follow DOI / PubMed links for the primary literature; publisher figures and PDF images are not displayed here.

Source text excerpt ation; ation; PMID 22215681, recombinant expression in E. coli, in vitro assay with microsomes, GC-MS and NMR characterization.

Reaction & quality gates

Mechanism
Hydroxylation
Evidence type
In vitro
Confidence
High
Data tier
Silver
mass=no_smiles; incomplete_SMILES
Substrate class
Terpenoids
Product class
Terpenoids

Literature & public identifiers

PubMed
PMID:22215681 ↗
DOI
10.1074/jbc.m111.305599 ↗
UniProt
Q6YTF1 ↗
GenBank
NCBI TaxID
4530 ↗

Characterization of CYP76M5-8 indicates metabolic plasticity within a plant biosynthetic gene cluster.