ElADH1

Euphorbia lathyris

Euphorbiaceae

Substrate reaction site Product reaction site MCS substructure diff highlighting · RDKit atom mapping

Substrate

5-keto-6,9-casbenediol

PubChem ↗ Crowdsource substrate structure

ElADH1

ΔMass: no_smiles Missing dual SMILES or RDKit not validated

Product

jolkinol C

PubChem ↗ C[C@H]1C[C@]2([C@H](C1=O)/C=C(/CC[C@H]3[C@H](C3(C)C)/C=C(/C2=O)…

Evidence trail

Excerpts are machine-extracted plain text for biochemical provenance. Follow DOI / PubMed links for the primary literature; publisher figures and PDF images are not displayed here.

Source text excerpt ation; ation; ADH1 catalyzes dehydrogenation of trioxygenated casbene derivative 7 to form cyclized lathyrane diterpene jolkinol C; confirmed by in vitro enzyme assays and in vivo N. benthamiana expression.

Reaction & quality gates

Mechanism: Oxidation
Evidence type: In vitro
Confidence: High
Data tier: Silver
mass=no_smiles; incomplete_SMILES
Substrate class: Other
Product class: Other

Literature & public identifiers

PubMed: PMID:27506796 ↗
DOI: 10.1073/pnas.1607504113 ↗
UniProt: KR350665 ↗
GenBank: KR350665 ↗
NCBI TaxID: 212925 ↗

Oxidation and cyclization of casbene in the biosynthesis of Euphorbia factors from mature seeds of Euphorbia lathyris L.

Evidence trail

Reaction & quality gates

Literature & public identifiers

Other reactions by this enzyme