CYP72A613

Repeated evolution CYP72A

Substrate reaction site Product reaction site MCS substructure diff highlighting · RDKit atom mapping

Substrate

16-hydroxy-22-oxo-cholesterol

PubChem ↗ CC(C)CCC(=O)[C@@H](C)[C@H]1C(O)C[C@H]2[C@@H]3CC=C4C[C@@H](O)CC[…

CYP72A613

ΔMass: -2.0157 Da fallback:~-2 Da (成酮/脱氢)

Product

diosgenin

PubChem ↗ C[C@@H]1CC[C@@]2([C@H]([C@H]3[C@@H](O2)C[C@@H]4[C@@]3(CC[C@H]5[…

Evidence trail

Excerpts are machine-extracted plain text for biochemical provenance. Follow DOI / PubMed links for the primary literature; publisher figures and PDF images are not displayed here.

Source text excerpt ization; ization; In vivo in N. benthamiana co-expression with TfCYP90B50; no in vitro data.

Reaction & quality gates

Mechanism: Ketone formation (-2.02 Da)
Evidence type: In vivo
Confidence: Medium
Data tier: Gold
Latin binomial + experiment + dual SMILES + ΔMass pass
Substrate class: Steroids
Product class: Other

Literature & public identifiers

PubMed: PMID:31324795 ↗
DOI: 10.1038/s41467-019-11286-7 ↗
UniProt: A0A517FNC9 ↗
GenBank: —
NCBI TaxID: —

Repeated evolution of cytochrome P450-mediated spiroketal steroid biosynthesis in plants.