CYP712K3

Tripterygium wilfordii CYP712K

Celastraceae

Substrate reaction site Product reaction site MCS substructure diff highlighting · RDKit atom mapping

Substrate

29-oxo-friedelin

PubChem ↗ Crowdsource substrate structure

CYP712K3

ΔMass: no_smiles Missing dual SMILES or RDKit not validated

Product

polpunonic acid

PubChem ↗ C[C@H]1C(=O)CC[C@@H]2[C@@]1(CC[C@H]3[C@]2(CC[C@@]4([C@@]3(CC[C@…

Evidence trail

Excerpts are machine-extracted plain text for biochemical provenance. Follow DOI / PubMed links for the primary literature; publisher figures and PDF images are not displayed here.

Source text excerpt ation; ation; Third sequential oxidation; product confirmed by NMR.

Reaction & quality gates

Mechanism: Oxidation
Evidence type: In vivo
Confidence: High
Data tier: Silver
mass=no_smiles; incomplete_SMILES
Substrate class: Other
Product class: Organic acids

Literature & public identifiers

PubMed: PMID:31992268 ↗
DOI: 10.1186/s12934-020-1284-9 ↗
UniProt: —
GenBank: —
NCBI TaxID: 458696 ↗

Integrating pathway elucidation with yeast engineering to produce polpunonic acid the precursor of the anti-obesity agent celastrol.

Evidence trail

Reaction & quality gates

Literature & public identifiers

Other reactions by this enzyme