CYP749B1

Withania somnifera CYP749B

Solanaceae

Substrate reaction site Product reaction site MCS substructure diff highlighting · RDKit atom mapping

Substrate

cycloartenol

PubChem ↗ C[C@H](CCC=C(C)C)[C@H]1CC[C@@]2([C@@]1(CC[C@]34[C@H]2CC[C@@H]5[…

CYP749B1

ΔMass: Exempt atypical_cleavage_exempt

Product

sitosterol

PubChem ↗ CC[C@H](CC[C@@H](C)[C@H]1CC[C@@H]2[C@@]1(CC[C@H]3[C@H]2CC=C4[C@…

Evidence trail

Excerpts are machine-extracted plain text for biochemical provenance. Follow DOI / PubMed links for the primary literature; publisher figures and PDF images are not displayed here.

Source text excerpt ation; ation; PMID 39124289, Table 2: WsHMGR2 overexpression increased cycloartenol, sitosterol, stigmasterol, and campesterol. CYP749B1 listed as involved; substrate-product pair inferred from pathway.

Reaction & quality gates

Mechanism: Atypical_Cleavage (Hydroperoxide lyase)
Evidence type: In vivo
Confidence: High
Data tier: Special
Atypical P450 cleavage (CYP74); ΔMass exempt
Substrate class: Other
Product class: Steroids

Literature & public identifiers

PubMed: PMID:39124289 ↗
DOI: 10.3390/plants13152171 ↗
UniProt: B3RFJ8 ↗
GenBank: —
NCBI TaxID: 126910 ↗

Enhancing Withanolide Production in the <i>Withania</i> Species: Advances in In Vitro Culture and Synthetic Biology Approaches.

Evidence trail

Reaction & quality gates

Literature & public identifiers

Other reactions by this enzyme