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Silver no_smiles Hydroxylation

CYP712K2

Tripterygium wilfordii CYP712K

Celastraceae

Substrate reaction site Product reaction site MCS substructure diff highlighting · RDKit atom mapping
Substrate
friedelin
PubChem ↗ C[C@H]1C(=O)CC[C@@H]2[C@@]1(CC[C@H]3[C@]2(CC[C@@]4([C@@]3(CC[C@…
CYP712K2
ΔMass: no_smiles Missing dual SMILES or RDKit not validated
Product
triptolide precursor
PubChem ↗ Crowdsource product structure

Evidence trail

Excerpts are machine-extracted plain text for biochemical provenance. Follow DOI / PubMed links for the primary literature; publisher figures and PDF images are not displayed here.

Source text excerpt ation; ation; Tripterygium wilfordii; hydroxylates C-3 position of friedelin.

Reaction & quality gates

Mechanism
Hydroxylation
Evidence type
In vitro
Confidence
High
Data tier
Silver
mass=no_smiles; incomplete_SMILES
Substrate class
Other
Product class
Other

Literature & public identifiers

PubMed
PMID:41799975 ↗
DOI
10.3389/fpls.2026.1765290 ↗
UniProt
QYZ87004.1 ↗
GenBank
CYP712K2 ↗
NCBI TaxID
458696 ↗

Cytochrome P450 gene family: cross-pathway functional conservation, novel catalytic reactions, and synthetic biology-driven applications in plant secondary metabolism.