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Silver no_smiles Hydroxylation

HPO

Hyoscyamus muticus CYP71D

Solanaceae

Substrate reaction site Product reaction site MCS substructure diff highlighting · RDKit atom mapping
Substrate
4-epi-eremophilene
PubChem ↗ C[C@@H]1CCC=C2[C@@]1(C[C@@H](CC2)C(=C)C)C
HPO
ΔMass: no_smiles Missing dual SMILES or RDKit not validated
Product
2β-hydroxy-4-epi-eremophilene
PubChem ↗ Crowdsource product structure

Evidence trail

Excerpts are machine-extracted plain text for biochemical provenance. Follow DOI / PubMed links for the primary literature; publisher figures and PDF images are not displayed here.

Source text excerpt ation; ation; HPO catalyzes hydroxylation at C-2 of 4-epi-eremophilene to form 2β-hydroxy EE as dominant product; evidence from yeast microsome assays.

Reaction & quality gates

Mechanism
Hydroxylation
Evidence type
In vitro
Confidence
High
Data tier
Silver
mass=no_smiles; incomplete_SMILES
Substrate class
Other
Product class
Other

Literature & public identifiers

PubMed
PMID:17715131 ↗
DOI
10.1074/jbc.m703378200 ↗
UniProt
A6YIH8 ↗
GenBank
NCBI TaxID
35626 ↗

Functional characterization of premnaspirodiene oxygenase, a cytochrome P450 catalyzing regio- and stereo-specific hydroxylations of diverse sesquiterpene substrates.