ADHL1

Catharanthus roseus

Apocynaceae

Substrate reaction site Product reaction site MCS substructure diff highlighting · RDKit atom mapping

Substrate

16-methoxytabersonine

PubChem ↗ CC[C@]12CC(=C3[C@@]4([C@H]1N(CC4)CC=C2)C5=C(N3)C=C(C=C5)OC)C(=O…

ADHL1

ΔMass: +18.0106 Da mismatch

Product

3-hydroxy-16-methoxy-2,3-dihydrotabersonine

PubChem ↗ CC[C@]12C[C@@]([C@H]3[C@@]4([C@H]1N(CC4)CC=C2)C5=C(N3)C=C(C=C5)…

Evidence trail

Excerpts are machine-extracted plain text for biochemical provenance. Follow DOI / PubMed links for the primary literature; publisher figures and PDF images are not displayed here.

Source text excerpt Other; Other; VIGS silencing of ADHL1 in C. roseus leads to accumulation of epoxide isomers and reduction of desacetoxyvindoline; coupled with T3O in planta.

Reaction & quality gates

Mechanism: Other
Evidence type: In vivo
Confidence: High
Data tier: Silver
mass=mismatch
Substrate class: Other
Product class: Other

Literature & public identifiers

PubMed: PMID:25918424 ↗
DOI: 10.1073/pnas.1501821112 ↗
UniProt: KP122966 ↗
GenBank: KP122966 ↗
NCBI TaxID: 4058 ↗

Completion of the seven-step pathway from tabersonine to the anticancer drug precursor vindoline and its assembly in yeast.

Evidence trail

Reaction & quality gates

Literature & public identifiers

Other reactions by this enzyme