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Silver no_smiles Hydroxylation

CYP712K1

Tripterygium wilfordii CYP712K

Celastraceae

Substrate reaction site Product reaction site MCS substructure diff highlighting · RDKit atom mapping
Substrate
friedelin
PubChem ↗ C[C@H]1C(=O)CC[C@@H]2[C@@]1(CC[C@H]3[C@]2(CC[C@@]4([C@@]3(CC[C@…
CYP712K1
ΔMass: no_smiles Missing dual SMILES or RDKit not validated
Product
29-hydroxy-friedelin
PubChem ↗ Crowdsource product structure

Evidence trail

Excerpts are machine-extracted plain text for biochemical provenance. Follow DOI / PubMed links for the primary literature; publisher figures and PDF images are not displayed here.

Source text excerpt ation; ation; Co-expression with TwOSC4 in N. benthamiana; product identified by NMR.

Reaction & quality gates

Mechanism
Hydroxylation
Evidence type
In vivo
Confidence
High
Data tier
Silver
mass=no_smiles; incomplete_SMILES
Substrate class
Other
Product class
Other

Literature & public identifiers

PubMed
PMID:31992268 ↗
DOI
10.1186/s12934-020-1284-9 ↗
UniProt
WQI83062.1 ↗
GenBank
CYP712K1 ↗
NCBI TaxID
458696 ↗

Integrating pathway elucidation with yeast engineering to produce polpunonic acid the precursor of the anti-obesity agent celastrol.