← Back to reactions
Quarantine mismatch Oxidation

FLS

Roles of

Substrate reaction site Product reaction site MCS substructure diff highlighting · RDKit atom mapping
Substrate
(2R,3S)-cis-DHK
PubChem ↗ CC(=O)N[C@H]1C(O)O[C@H](CO)[C@@H](O[C@@H]2O[C@H](CO[C@H]3O[C@H]…
FLS
ΔMass: -1879.6761 Da mismatch
Product
Kaempferol
PubChem ↗ C1=CC(=CC=C1C2=C(C(=O)C3=C(C=C(C=C3O2)O)O)O)O

Evidence trail

Excerpts are machine-extracted plain text for biochemical provenance. Follow DOI / PubMed links for the primary literature; publisher figures and PDF images are not displayed here.

Source text excerpt ation; ation; PMID 34771153, Table 1: FLS activity with (2R,3S)-cis-DHK to kaempferol, verified in vitro.

Reaction & quality gates

Mechanism
Oxidation
Evidence type
In vitro
Confidence
Medium
Data tier
Quarantine
non-CYP auxiliary enzyme (pathway partner, not cytochrome P450)
Substrate class
Other
Product class
Phenylpropanoids

Literature & public identifiers

PubMed
PMID:34771153 ↗
DOI
10.3390/molecules26216745 ↗
UniProt
Q9XHG2 ↗
GenBank
NCBI TaxID

Roles of the 2-Oxoglutarate-Dependent Dioxygenase Superfamily in the Flavonoid Pathway: A Review of the Functional Diversity of F3H, FNS I, FLS, and LDOX/ANS.