FLS

Roles of

Substrate reaction site Product reaction site MCS substructure diff highlighting · RDKit atom mapping

Substrate

(2S)-Naringenin

PubChem ↗ C1[C@H](OC2=CC(=CC(=C2C1=O)O)O)C3=CC=C(C=C3)O

FLS

ΔMass: -2.0157 Da ketone_formation(-2.0157)

Product

Apigenin

PubChem ↗ C1=CC(=CC=C1C2=CC(=O)C3=C(C=C(C=C3O2)O)O)O

Evidence trail

Excerpts are machine-extracted plain text for biochemical provenance. Follow DOI / PubMed links for the primary literature; publisher figures and PDF images are not displayed here.

Source text excerpt ation; ation; PMID 34771153, Table 1: FLS activity with (2S)-naringenin to kaempferol and apigenin, verified in vitro.

Reaction & quality gates

Mechanism: Ketone formation (-2.02 Da)
Evidence type: In vitro
Confidence: Medium
Data tier: Quarantine
non-CYP auxiliary enzyme (pathway partner, not cytochrome P450)
Substrate class: Phenylpropanoids
Product class: Phenylpropanoids

Literature & public identifiers

PubMed: PMID:34771153 ↗
DOI: 10.3390/molecules26216745 ↗
UniProt: Q9XHG2 ↗
GenBank: —
NCBI TaxID: —

Roles of the 2-Oxoglutarate-Dependent Dioxygenase Superfamily in the Flavonoid Pathway: A Review of the Functional Diversity of F3H, FNS I, FLS, and LDOX/ANS.

Evidence trail

Reaction & quality gates

Literature & public identifiers

Other reactions by this enzyme