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Quarantine mismatch Hydroxylation

FLS

Roles of

Substrate reaction site Product reaction site MCS substructure diff highlighting · RDKit atom mapping
Substrate
(2R)-Naringenin
PubChem ↗ C1[C@@H](OC2=CC(=CC(=C2C1=O)O)O)C3=CC=C(C=C3)O
FLS
ΔMass: +2096.7347 Da mismatch
Product
(2S,3S)-trans-DHK
PubChem ↗ CC(=O)N[C@H]1[C@H](O[C@H]2[C@H](O)[C@@H](NC(C)=O)C(O)O[C@@H]2CO…

Evidence trail

Excerpts are machine-extracted plain text for biochemical provenance. Follow DOI / PubMed links for the primary literature; publisher figures and PDF images are not displayed here.

Source text excerpt ation; ation; PMID 34771153, Table 1: FLS activity with (2R)-naringenin to (2S,3S)-trans-DHK, verified in vitro.

Reaction & quality gates

Mechanism
Hydroxylation
Evidence type
In vitro
Confidence
Medium
Data tier
Quarantine
non-CYP auxiliary enzyme (pathway partner, not cytochrome P450)
Substrate class
Phenylpropanoids
Product class
Other

Literature & public identifiers

PubMed
PMID:34771153 ↗
DOI
10.3390/molecules26216745 ↗
UniProt
Q9XHG2 ↗
GenBank
NCBI TaxID

Roles of the 2-Oxoglutarate-Dependent Dioxygenase Superfamily in the Flavonoid Pathway: A Review of the Functional Diversity of F3H, FNS I, FLS, and LDOX/ANS.