CYP71D375

Salvia miltiorrhiza CYP71D

Lamiaceae

Substrate reaction site Product reaction site MCS substructure diff highlighting · RDKit atom mapping

Substrate

miltirone

PubChem ↗ CC(C)C1=CC2=C(C3=C(C=C2)C(CCC3)(C)C)C(=O)C1=O

CYP71D375

ΔMass: +13.9793 Da mismatch

Product

cryptotanshinone

PubChem ↗ C[C@H]1COC2=C1C(=O)C(=O)C3=C2C=CC4=C3CCCC4(C)C

Evidence trail

Excerpts are machine-extracted plain text for biochemical provenance. Follow DOI / PubMed links for the primary literature; publisher figures and PDF images are not displayed here.

Source text excerpt Other; Other; CYP71D375 catalyzes heterocyclization of miltirone (4) to cryptotanshinone (1) via 14,16-ether formation. In vitro assay with recombinant yeast microsomes, product identified by comparison to authentic standard.

Reaction & quality gates

Mechanism: Other
Evidence type: In vitro
Confidence: High
Data tier: Silver
mass=mismatch
Substrate class: Other
Product class: Terpenoids

Literature & public identifiers

PubMed: PMID:33514704 ↗
DOI: 10.1038/s41467-021-20959-1 ↗
UniProt: A0A5A4JQD7 ↗
GenBank: —
NCBI TaxID: 226208 ↗

Expansion within the CYP71D subfamily drives the heterocyclization of tanshinones synthesis in Salvia miltiorrhiza.

Evidence trail

Reaction & quality gates

Literature & public identifiers

Other reactions by this enzyme