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Silver no_smiles Hydroxylation

CYP71D375

Salvia miltiorrhiza CYP71D

Lamiaceae

Substrate reaction site Product reaction site MCS substructure diff highlighting · RDKit atom mapping
Substrate
miltirone
PubChem ↗ CC(C)C1=CC2=C(C3=C(C=C2)C(CCC3)(C)C)C(=O)C1=O
CYP71D375
ΔMass: no_smiles Missing dual SMILES or RDKit not validated
Product
16-hydroxymiltirone
PubChem ↗ Crowdsource product structure

Evidence trail

Excerpts are machine-extracted plain text for biochemical provenance. Follow DOI / PubMed links for the primary literature; publisher figures and PDF images are not displayed here.

Source text excerpt ation; ation; Minor product from CYP71D375 with miltirone (4), identified as 16-hydroxymiltirone (7) by NMR.

Reaction & quality gates

Mechanism
Hydroxylation
Evidence type
In vitro
Confidence
High
Data tier
Silver
mass=no_smiles; incomplete_SMILES
Substrate class
Other
Product class
Other

Literature & public identifiers

PubMed
PMID:33514704 ↗
DOI
10.1038/s41467-021-20959-1 ↗
UniProt
A0A5A4JQD7 ↗
GenBank
NCBI TaxID
226208 ↗

Expansion within the CYP71D subfamily drives the heterocyclization of tanshinones synthesis in Salvia miltiorrhiza.