CYP71D375

Salvia miltiorrhiza CYP71D

Lamiaceae

Substrate reaction site Product reaction site MCS substructure diff highlighting · RDKit atom mapping

Substrate

miltirone

PubChem ↗ CC(C)C1=CC2=C(C3=C(C=C2)C(CCC3)(C)C)C(=O)C1=O

CYP71D375

ΔMass: +31.9898 Da mismatch

Product

neocryptotanshinone

PubChem ↗ C[C@@H](CO)C1=C(C2=C(C3=C(C=C2)C(CCC3)(C)C)C(=O)C1=O)O

Evidence trail

Excerpts are machine-extracted plain text for biochemical provenance. Follow DOI / PubMed links for the primary literature; publisher figures and PDF images are not displayed here.

Source text excerpt ation; ation; Minor product from CYP71D375 with miltirone (4), identified as 14,16-dihydroxy derivative neocryptotanshinone (8) by comparison to authentic standard.

Reaction & quality gates

Mechanism: Hydroxylation
Evidence type: In vitro
Confidence: High
Data tier: Silver
mass=mismatch
Substrate class: Other
Product class: Terpenoids

Literature & public identifiers

PubMed: PMID:33514704 ↗
DOI: 10.1038/s41467-021-20959-1 ↗
UniProt: A0A5A4JQD7 ↗
GenBank: —
NCBI TaxID: 226208 ↗

Expansion within the CYP71D subfamily drives the heterocyclization of tanshinones synthesis in Salvia miltiorrhiza.

Evidence trail

Reaction & quality gates

Literature & public identifiers

Other reactions by this enzyme