CYP71D375

Salvia miltiorrhiza CYP71D

Lamiaceae

Substrate reaction site Product reaction site MCS substructure diff highlighting · RDKit atom mapping

Substrate

PubChem ↗ C=CCN(C)CCCCCCOc1ccc(C(=O)c2ccc(Br)cc2)c(F)c1.O=C(O)/C=C/C(=O)O

CYP71D375

ΔMass: -285.0376 Da mismatch

Product

15,16-dihydrotanshinone I

PubChem ↗ C[C@H]1COC2=C1C(=O)C(=O)C3=C2C=CC4=C(C=CC=C43)C

Evidence trail

Excerpts are machine-extracted plain text for biochemical provenance. Follow DOI / PubMed links for the primary literature; publisher figures and PDF images are not displayed here.

Source text excerpt Other; Other; CYP71D375 converts Ro (5) to 15,16-dihydrotanshinone I (2) via heterocyclization. Major product identified by comparison to authentic standard.

Reaction & quality gates

Mechanism: Other
Evidence type: In vitro
Confidence: High
Data tier: Silver
mass=mismatch
Substrate class: Other
Product class: Terpenoids

Literature & public identifiers

PubMed: PMID:33514704 ↗
DOI: 10.1038/s41467-021-20959-1 ↗
UniProt: A0A5A4JQD7 ↗
GenBank: —
NCBI TaxID: 226208 ↗

Expansion within the CYP71D subfamily drives the heterocyclization of tanshinones synthesis in Salvia miltiorrhiza.

Evidence trail

Reaction & quality gates

Literature & public identifiers

Other reactions by this enzyme